THE CORRELATION BETWEEN INTERFERON LAMBDA 3 GENE POLYMORPHISMS AND SUSCEPTIBILITY TO HEPATITIS B VIRUS INFECTION

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HEIDARI ZAHRA; MOUDI BITA; MAHMOUDZADEH SAGHEB HAMIDREZA; HASHEMI MOHAMMAD

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Journal: Hepatitis Monthly Year:2016 | Volume:16 | Issue:3 Page(s): 0-0

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Title

THE CORRELATION BETWEEN INTERFERON LAMBDA 3 GENE POLYMORPHISMS AND SUSCEPTIBILITY TO HEPATITIS B VIRUS INFECTION

Author(s)

HEIDARI ZAHRA | MOUDI BITA | MAHMOUDZADEH SAGHEB HAMIDREZA | HASHEMI MOHAMMAD | Issue Writer Certificate

Keywords

GENETIC POLYMORPHISM

CHRONIC HEPATITIS B

INTERFERON LAMBDA 3 (IFNL3)

Abstract

Background: Cytokines are proteins that mediate innate and adaptive immunity responses. It is hypothesized that interferon lambda 3 (IFNL3) levels can influence the outcome of CHRONIC HEPATITIS B virus (HBV) infection. Polymorphisms in IFN genes have been associated with response to infection.Objectives: This study was carried-out to investigate the association of IFNL3 gene polymorphisms (rs12979860 and rs8099917) with HBV susceptibility, in chronic HBV-infected patients.Patients and Methods: In this case-control study, we determined IFNL3 single nucleotide polymorphisms (SNPs) (rs12979860 and rs8099917) in 221 individuals, with chronic HBV infection, and 200 healthy individuals, who were voluntary blood donors, with negative test for HBV. Alleles and genotypes analyses were performed by amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods.Results: The frequencies of the rs12979860 and rs8099917 genotypes were not significantly different between the HBV-infected and the control groups (CC: CT: TT of 30.3%: 48.0%: 21.7% vs.33.0%: 49.0%: 18.0%, P>0.05, and GG: GT: TT of 5.8%: 39.4%: 54.8% vs.5.0%: 41.0%: 54.0%, P >0.05, respectively). Also, the frequencies of the alleles were not significantly different between both groups (C: T of 54.3%: 45.7% vs.57.5%: 42.5%, P>0.05, and G: T of 25.6%: 74.4% vs.25.5%: 74.5%, P>0.05, respectively) and the chronic HBV infection. There were no significant differences between patients, with at least one rs12979860Candor rs8099917T allelescomparedto the healthy controls (rs12979860: CT+CC: TT, OR=1.26, 95%CI=0.78 - 2.04, P=0.341 and rs8099917: GT+TT: GG, OR=1.03, 95%CI=0.70 - 1.51, P=0.877, respectively).Conclusions: Our study showed no correlation between rs12979860 and rs8099917 SNPs and chronic HBV infection. Further studies, with larger sample sizes and different ethnicities, are necessary to validate our findings.

Cites

The relationship between L‑ leucine‑ 7‑ amido ‑ 4‑ methyl coumarin 1 gene polymorphism and susceptibility to the chronic hepatitis B virus infection in an Iranian population

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APA: Copy

HEIDARI, ZAHRA, MOUDI, BITA, MAHMOUDZADEH SAGHEB, HAMIDREZA, & HASHEMI, MOHAMMAD. (2016). THE CORRELATION BETWEEN INTERFERON LAMBDA 3 GENE POLYMORPHISMS AND SUSCEPTIBILITY TO HEPATITIS B VIRUS INFECTION. HEPATITIS MONTHLY, 16(3), 0-0. SID. https://sid.ir/paper/306980/en

Vancouver: Copy

HEIDARI ZAHRA, MOUDI BITA, MAHMOUDZADEH SAGHEB HAMIDREZA, HASHEMI MOHAMMAD. THE CORRELATION BETWEEN INTERFERON LAMBDA 3 GENE POLYMORPHISMS AND SUSCEPTIBILITY TO HEPATITIS B VIRUS INFECTION. HEPATITIS MONTHLY[Internet]. 2016;16(3):0-0. Available from: https://sid.ir/paper/306980/en

IEEE: Copy

ZAHRA HEIDARI, BITA MOUDI, HAMIDREZA MAHMOUDZADEH SAGHEB, and MOHAMMAD HASHEMI, “THE CORRELATION BETWEEN INTERFERON LAMBDA 3 GENE POLYMORPHISMS AND SUSCEPTIBILITY TO HEPATITIS B VIRUS INFECTION,” HEPATITIS MONTHLY, vol. 16, no. 3, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/306980/en

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