THE ASSOCIATION OF PRE-S/S GENE MUTATIONS AND HEPATITIS B VIRUS VERTICAL TRANSMISSION

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YIN YUZHU; ZHANG PEIZHEN; TAN ZHANGMIN; ZHOU JIN; WU LINGLING; HOU HONGYING

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Journal: Hepatitis Monthly Year:2016 | Volume:16 | Issue:3 Page(s): 0-0

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Title

THE ASSOCIATION OF PRE-S/S GENE MUTATIONS AND HEPATITIS B VIRUS VERTICAL TRANSMISSION

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Keywords

HEPATITIS B VIRUS

PRE-S/S

MUTATION

VACCINATION FAILURE

Abstract

Background: HBV PRE-S/S gene MUTATIONs can occur before or after implementation of combined vaccination program. HBV Prs-S/S gene MUTATION is a risk factor of VACCINATION FAILURE and frequently causes HBV vertical transfection.Objectives: To assess the association of HEPATITIS B VIRUS (HBV) S gene MUTATIONs with vertical transmission.Patients and Methods: In this prospective nested case-control study, a total of 60 pregnant women with positive serum HBsAg and HBV DNA³107 IU/mL were divided into a case group (15 cases with VACCINATION FAILURE) and a control group (45 cases with vaccination success) according to whether their infants tested positive for HBV infection. Mothers and their children in the case group were further sub-divided into groups including mothers, newborns and infant (the same newborns at age of seven months). The PRE-S/S gene MUTATIONs were detected by PCR and sequenced and its association with vertical transmission of HBV was analyzed.Results: HBV genotype B was the dominant genotype in the both groups’ mothers. Each mother-child pair in case group had the same HBV genotype. There were no significant differences in MUTATION frequencies of HBV PRE-S/S gene between case and control groups’ mothers (Fragment 1 (M): 2 vs.4, P>0.05; Fragment 2 (M): 10 vs.10, P>0.05), or among the mothers, newborns and infants in the case group (Fragment 1 (M): 2, 2, and 3, respectively, P>0.05; Fragment 2 (M): 10, 10 and 10 respectively, P>0.05). MUTATION site analysis of the both groups’ mothers demonstrated 108 different MUTATION sites in the HBV PRE-S/S gene, with 105 silent MUTATIONs and 5 missense MUTATIONs including ntA826G, ntC531T, ntT667C, ntC512T and ntC546A. Among 15 mother-newborn-infant pairs with successful PCR and sequence in case group, 7 (41.17%) mother-newborn pairs, 9 (60.00%) mother-infant pairs and 3 (20.00%) infant-newborn pairs had different MUTATION sites.Conclusions: HBV in children due to VACCINATION FAILURE was resulted from vertical transmission. HBV PRE-S/S gene MUTATIONs were prevalent and could occur before or after vaccination. Therefore, simply analyzing MUTATION frequency of HBV gene was not of value.To advance blocking HBV vertical transmission, future studies should focus on specific MUTATION sites, potentially associated with VACCINATION FAILURE.

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APA: Copy

YIN, YUZHU, ZHANG, PEIZHEN, TAN, ZHANGMIN, ZHOU, JIN, WU, LINGLING, & HOU, HONGYING. (2016). THE ASSOCIATION OF PRE-S/S GENE MUTATIONS AND HEPATITIS B VIRUS VERTICAL TRANSMISSION. HEPATITIS MONTHLY, 16(3), 0-0. SID. https://sid.ir/paper/306987/en

Vancouver: Copy

YIN YUZHU, ZHANG PEIZHEN, TAN ZHANGMIN, ZHOU JIN, WU LINGLING, HOU HONGYING. THE ASSOCIATION OF PRE-S/S GENE MUTATIONS AND HEPATITIS B VIRUS VERTICAL TRANSMISSION. HEPATITIS MONTHLY[Internet]. 2016;16(3):0-0. Available from: https://sid.ir/paper/306987/en

IEEE: Copy

YUZHU YIN, PEIZHEN ZHANG, ZHANGMIN TAN, JIN ZHOU, LINGLING WU, and HONGYING HOU, “THE ASSOCIATION OF PRE-S/S GENE MUTATIONS AND HEPATITIS B VIRUS VERTICAL TRANSMISSION,” HEPATITIS MONTHLY, vol. 16, no. 3, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/306987/en

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