ANALYSIS OF CROSS-OVER CLINICAL TRIALS WITH BINARY NON-COMPLIANCE VARIABLE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SOLTANIAN ALI REZA; FAGHIHZADEH SOGHRAT; GERAMI ABBAS; MEHDI BARZI DARIUSH; CHENG JING

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: DANESHVAR MEDICINE Year:2010 | Volume:16 | Issue:84 Page(s): 55-62

Download Full-Text

Persian Verion

View:

2,052

Download:

Cites:

Information Journal Paper

Title

ANALYSIS OF CROSS-OVER CLINICAL TRIALS WITH BINARY NON-COMPLIANCE VARIABLE

Author(s)

Keywords

CROSSOVER CLINICAL TRIALSQ3

INTENTION-TO-TREATQ3

NONCOMPLIANCEQ3

PRINCIPAL COMPONENT ANALYSISQ3

Abstract

Background and Objective: A one of the most power on assesses treatment effect is doubled-blind clinical trial. Therefore, deviation of protocol would impede the results in clinical trial. In practice (especially in studies which intervention is drug medication) is non-compliance. Researchers use INTENTION-TO-TREAT analysis for estimation of treatment effects in clinical trials with non-compliance. When there is NONCOMPLIANCE in participants, ITT estimation will have lower precision. In this paper we adjusted NONCOMPLIANCE effect to compare of active treatment and placebo.Materials and Methods: In this paper we used Mehdi-Barzy' study data that was a placebo control, double blind crossover clinical trial and the objective of this study in 42 patients was to assess efficacy of herbal pomade “A” (analgesic effect and improvement function) using locally in patients with primary knee osteoarthritis over 3 weeks. Our model adjusted INTENTION-TO-TREAT estimand under conditional compliance estimation.Results: In the study 42 patients were participate with 30 (71.4%) women. Baseline variables like sex, age, education, weight, height are same in herbal joint and placebo groups. Portions of NONCOMPLIANCE in first and second period were 35.7 and 23.8 percent, respectively, in Mehdi-Barzy' study that based on ITT was adjusted. Standard error and likelihood ratio based on our model were less than standard model.Conclusion: ITT estimand base on our model is better than standard ITT estimand in compare to active treatment and placebo effects.

Cites

No record.

References

No record.

Cite

APA: Copy

SOLTANIAN, ALI REZA, FAGHIHZADEH, SOGHRAT, GERAMI, ABBAS, MEHDI BARZI, DARIUSH, & CHENG, JING. (2010). ANALYSIS OF CROSS-OVER CLINICAL TRIALS WITH BINARY NON-COMPLIANCE VARIABLE. DANESHVAR MEDICINE, 16(84), 55-62. SID. https://sid.ir/paper/30722/en

Vancouver: Copy

SOLTANIAN ALI REZA, FAGHIHZADEH SOGHRAT, GERAMI ABBAS, MEHDI BARZI DARIUSH, CHENG JING. ANALYSIS OF CROSS-OVER CLINICAL TRIALS WITH BINARY NON-COMPLIANCE VARIABLE. DANESHVAR MEDICINE[Internet]. 2010;16(84):55-62. Available from: https://sid.ir/paper/30722/en

IEEE: Copy

ALI REZA SOLTANIAN, SOGHRAT FAGHIHZADEH, ABBAS GERAMI, DARIUSH MEHDI BARZI, and JING CHENG, “ANALYSIS OF CROSS-OVER CLINICAL TRIALS WITH BINARY NON-COMPLIANCE VARIABLE,” DANESHVAR MEDICINE, vol. 16, no. 84, pp. 55–62, 2010, [Online]. Available: https://sid.ir/paper/30722/en

Related Journal Papers