THE EFFECT OF FLUOXETIN ON HOT FLASHES IN MENOPAUSED WOMEN

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YAZDIZADEH V.; MODARES GILANI M.; KAZEMNEJAD ANOUSHIRAVAN

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Journal: DANESHVAR MEDICINE Year:2009 | Volume:16 | Issue:81 Page(s): 23-28

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Title

THE EFFECT OF FLUOXETIN ON HOT FLASHES IN MENOPAUSED WOMEN

Author(s)

YAZDIZADEH V. | MODARES GILANI M. | KAZEMNEJAD ANOUSHIRAVAN | Issue Writer Certificate

Keywords

FLUOXETINEQ3

HOT FLASHQ3

MENOPAUSEQ2

Abstract

Background: HOT FLASH is a common problem in climacteric (time course around MENOPAUSE) and menopausal period. The most effective treatment of it is HRT but there is a serious need for alternative therapies for HOT FLASHes, as hormone replacement therapy (HRT) is associated with increased rates of breast cancer and heart disease. Materials and Methods: This trial used a randomized, two-stage (4 weeks per stage), cross over methodology to study the efficacy of fluoxetin (20 mg/d) for treating HOT FLASHes in menopausal women (who atleast had 14 HOT FLASH attacks per week.) in first period, First group received 4 weeks of therapy with FLUOXETINE versus second group receiving placebo. During the next stage of treatment, patients were crossed over between two groups. The patients received no drug in the one week period interval between the two periods of study. (wash out). T-test, chi square, mann whitney, pair t-test, wilcocxon and fisher, tests were used for analysing data in spss software. Results: Eighty randomized women began protocol therapy. By the end of the first treatment period, HOT FLASH frequency decreased 55% in the fluoxetin arm versus 28% in the placebo arm. Cross over analyzing demonstrated a significantly greater marked improvement in HOT FLASH severity with fluoxetin than with placebo (p=0/00). Conclusion: Both Fluoxetin and placebo are effective in improving of HOT FLASHs but fluoxetin is significantly more effective. So FLUOXETINE is a realistic althernative theray for women who do not wish to receive hormones for fear of cancer or other reasons.

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APA: Copy

YAZDIZADEH, V., MODARES GILANI, M., & KAZEMNEJAD, ANOUSHIRAVAN. (2009). THE EFFECT OF FLUOXETIN ON HOT FLASHES IN MENOPAUSED WOMEN. DANESHVAR MEDICINE, 16(81), 23-28. SID. https://sid.ir/paper/30760/en

Vancouver: Copy

YAZDIZADEH V., MODARES GILANI M., KAZEMNEJAD ANOUSHIRAVAN. THE EFFECT OF FLUOXETIN ON HOT FLASHES IN MENOPAUSED WOMEN. DANESHVAR MEDICINE[Internet]. 2009;16(81):23-28. Available from: https://sid.ir/paper/30760/en

IEEE: Copy

V. YAZDIZADEH, M. MODARES GILANI, and ANOUSHIRAVAN KAZEMNEJAD, “THE EFFECT OF FLUOXETIN ON HOT FLASHES IN MENOPAUSED WOMEN,” DANESHVAR MEDICINE, vol. 16, no. 81, pp. 23–28, 2009, [Online]. Available: https://sid.ir/paper/30760/en

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