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Information Journal Paper

Title

SERUM SOLUBLE INTERLEUKIN-2 RECEPTOR ALPHA IN SYSTEMIC LUPUS ERYTHEMATOSUS

Pages

  80-85

Abstract

 Introduction: This study aimed at determination of circulating soluble interleukin-2 receptor (IL-2 R) alpha in the sera of patients with SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) and correlating the level of expression of these receptors with the SLE disease activity. Materials and Methods: The study included 55 patients with SLE and 20 healthy volunteers as controls. The following investigations were done: serum complement component 3, complement 4, erythrocyte sedimentation rate, complete blood count, serum creatinine, creatinine clearance, 24-hour urinary protein, urinalysis, and serum soluble IL-2R alpha level. Kidney biopsy was performed and examined with light microscopy for patients with lupus NEPHRITIS by a single pathologist blinded to the clinical activity of the disease. The results were analysed in relation to the clinical activity index of systemic lupus activity measure (SLAM). Results: The study showed that levels of soluble IL-2R alpha were significantly higher in the total group of patients with SLE compared to the controls (P<.001). Furthermore, serum IL-2R alpha levels were significantly higher in patients with lupus NEPHRITIS than those without NEPHRITIS. There were strong positive correlations between IL-2R alpha levels and the SLAM score, histological activity index, erythrocyte sedimentation rate, and 24-hour urinary protein excretion. Also, significant inverse correlations with complement 3 and packed cell volume was observed (r=0.738; r=0.669; r=0.328; r=0.705; r=-0.444; r=-0.420, respectively). Conclusions: Serum soluble IL-2R alpha is a reliable marker of disease activity in patients with SLE and could be used as an indicator of early renal involvement with the possibility of using it for follow-up.

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    APA: Copy

    EL SHAFEY, E.M., EL NAGAR, G.F., EL BENDARY, A.S., SABRY, A.A., & SELIM, A.G.A.. (2008). SERUM SOLUBLE INTERLEUKIN-2 RECEPTOR ALPHA IN SYSTEMIC LUPUS ERYTHEMATOSUS. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 2(2), 80-85. SID. https://sid.ir/paper/308663/en

    Vancouver: Copy

    EL SHAFEY E.M., EL NAGAR G.F., EL BENDARY A.S., SABRY A.A., SELIM A.G.A.. SERUM SOLUBLE INTERLEUKIN-2 RECEPTOR ALPHA IN SYSTEMIC LUPUS ERYTHEMATOSUS. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2008;2(2):80-85. Available from: https://sid.ir/paper/308663/en

    IEEE: Copy

    E.M. EL SHAFEY, G.F. EL NAGAR, A.S. EL BENDARY, A.A. SABRY, and A.G.A. SELIM, “SERUM SOLUBLE INTERLEUKIN-2 RECEPTOR ALPHA IN SYSTEMIC LUPUS ERYTHEMATOSUS,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 2, no. 2, pp. 80–85, 2008, [Online]. Available: https://sid.ir/paper/308663/en

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