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Cites:

1

Information Journal Paper

Title

URINARY N-ACETYL-BETA-D-GLUCOSAMINIDASE AS A DIAGNOSTIC MARKER OF ACUTE PYELONEPHRITIS IN CHILDREN

Pages

  24-28

Abstract

 Introduction: Prompt DIAGNOSIS and localization of pyelonephritis are of great importance in CHILDREN. The urinary excretion of enzymes, and in particular N-acetyl-beta-D-glucosaminidase (NAG), is considered a simple noninvasive marker for detection of renal tubular dysfunction due to pyelonephritis. This study was performed to determine the diagnostic value of urinary NAG in acute pyelonephritis. Materials and Methods: In a quasi-experimental study conducted on 72 CHILDREN with confirmed pyelonephritis, we measured urinary NAG, creatinine, and NAG-creatinine ratio before and after the treatment. Diagnostic values of these parameters were evaluated by considering the patients before and after the treatment as diseasepositive and disease-negative groups, respectively. Results: The patients were 18 boys (25.0%) and 54 girls (75.0%) with a mean age of 43.0±39.0 months. The mean levels of urinary NAG were 12.20±6.14 U/L and 5.46±7.98 U/L before and after the treatment, respectively (P<.001). The sensitivity and specificity of urinary NAG-creatinine ratio for DIAGNOSIS of pyelonephritis were 73.6% and 77.3%, respectively, with a cutoff point of 10.16 U/g (area under the curve=0.76, 95% confidence interval, 0.67 to 0.76). Significantly higher levels of urinary NAG were found in those who had a negative urine culture at DIAGNOSIS (8.8±10.4 U/L) compared to those with a positive urine culture (4.5±8.7 U/L). Conclusions: We concluded that urinary NAG is elevated in CHILDREN with pyelonephritis and it can be considered as a further criterion in the DIAGNOSIS of upper urinary tract infection.

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    • Cite

    APA: Copy

    MOHKAM, M., KARIMI, A.A., HABIBIAN, S., & SHARIFIAN, MOSTAFA. (2008). URINARY N-ACETYL-BETA-D-GLUCOSAMINIDASE AS A DIAGNOSTIC MARKER OF ACUTE PYELONEPHRITIS IN CHILDREN. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 2(1), 24-28. SID. https://sid.ir/paper/308670/en

    Vancouver: Copy

    MOHKAM M., KARIMI A.A., HABIBIAN S., SHARIFIAN MOSTAFA. URINARY N-ACETYL-BETA-D-GLUCOSAMINIDASE AS A DIAGNOSTIC MARKER OF ACUTE PYELONEPHRITIS IN CHILDREN. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2008;2(1):24-28. Available from: https://sid.ir/paper/308670/en

    IEEE: Copy

    M. MOHKAM, A.A. KARIMI, S. HABIBIAN, and MOSTAFA SHARIFIAN, “URINARY N-ACETYL-BETA-D-GLUCOSAMINIDASE AS A DIAGNOSTIC MARKER OF ACUTE PYELONEPHRITIS IN CHILDREN,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 2, no. 1, pp. 24–28, 2008, [Online]. Available: https://sid.ir/paper/308670/en

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