INTERLEUKIN-4 GENE POLYMORPHISMS IN TYPE 2 DIABETIC PATIENTS WITH NEPHROPATHY

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KAZEMI ARABABADI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Kidney Diseases Year:2010 | Volume:4 | Issue:4 Page(s): 302-306

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Information Journal Paper

Title

INTERLEUKIN-4 GENE POLYMORPHISMS IN TYPE 2 DIABETIC PATIENTS WITH NEPHROPATHY

Author(s)

KAZEMI ARABABADI M. | Issue Writer Certificate

Keywords

INTERLEUKIN-4

DIABETES MELLITUS

DIABETIC NEPHROPATHIES

POLYMORPHISM

Abstract

Introduction. The impact of several environmental and genetic factors on DIABETES MELLITUS and its complications is well documented. It has also been established that cytokines play key roles in the pathogenesis of nephropathy. POLYMORPHISMs of the -590 region of interleukin (IL)-4 are associated with the regulation of expression of this gene. In this study, we aimed to find POLYMORPHISMs of this region in nephropathic type 2 diabetic patients.Materials and Methods. Peripheral blood samples were collected from 100 type 2 diabetic patients with nephropathy and 150 healthy controls. DNA was extracted and a polymerase chain reaction restricted fragment length POLYMORPHISM technique was performed to examine POLYMORPHISMs in the -590 region of the IL-4 gene. Results. Our results showed a significant difference between the C/C, T/C, and T/T genotypes and the C and T alleles of the -590 region of IL-4 in nephropathic patients in comparison with the healthy controls.Conclusions. Results of this study suggest that the functional gene POLYMORPHISMs of IL-4 play an important role in the pathogenesis of diabetic nephropathy in patients with type 2 DIABETES MELLITUS.

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APA: Copy

KAZEMI ARABABADI, M.. (2010). INTERLEUKIN-4 GENE POLYMORPHISMS IN TYPE 2 DIABETIC PATIENTS WITH NEPHROPATHY. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 4(4), 302-306. SID. https://sid.ir/paper/309005/en

Vancouver: Copy

KAZEMI ARABABADI M.. INTERLEUKIN-4 GENE POLYMORPHISMS IN TYPE 2 DIABETIC PATIENTS WITH NEPHROPATHY. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2010;4(4):302-306. Available from: https://sid.ir/paper/309005/en

IEEE: Copy

M. KAZEMI ARABABADI, “INTERLEUKIN-4 GENE POLYMORPHISMS IN TYPE 2 DIABETIC PATIENTS WITH NEPHROPATHY,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 4, no. 4, pp. 302–306, 2010, [Online]. Available: https://sid.ir/paper/309005/en

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