EFFECT OF HEPATITIS C VIRUS ON C-REACTIVE PROTEIN AND INTERLEUKIN-6 IN HEMODIALYSIS PATIENTS

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AFZAL NADEEM; SARWAR ABBAS; AHMED AZAZMAND; ARIF MARIA; JAVEED KHURSHEED

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Journal: Iranian Journal of Kidney Diseases Year:2011 | Volume:5 | Issue:3 Page(s): 182-186

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Title

EFFECT OF HEPATITIS C VIRUS ON C-REACTIVE PROTEIN AND INTERLEUKIN-6 IN HEMODIALYSIS PATIENTS

Author(s)

Keywords

END-STAGE RENAL DISEASE

HEPATITIS C VIRUS

RENAL DIALYSIS

INTERLEUKIN-6

C-REACTIVE PROTEIN

Abstract

Introduction. Patients with END-STAGE RENAL DISEASE are at a high risk of HEPATITIS C VIRUS (HCV) infections. These patients are on maintenance hemodialysis where they are exposed to dialysis fluid and dialysis membrane that generate an acute-phase response, which leads to inflammation, reflected in increased inflammatory markers like C-REACTIVE PROTEIN (CRP) and INTERLEUKIN-6 (IL-6).The aim of this study was to investigate levels of IL-6 and CRP in patients on hemodialysis and to determine effects of HCV on these markers.Materials and Methods. A total of 43 patients (39.5% men and 60.5% women; age range, 21 to 65 years) on maintenance hemodialysis for a period of at least 3 months were included. Twenty-four of them were HCV positive. Serum IL-6 and CRP were assessed in all patients.Results. Of HCV-positive patients, 11 (45.8%) had high levels of CRP, while 13 (54.2%) had low levels and increased levels of IL-6 (1064±544.2 pg/mL, P=.19). Of 19 HCV-negative patients, 13 (68.4%) had high levels of CRP, while 6 (31.6%) had low levels, and all these patients had low levels of IL-6, as compared to HCVpositive patients. No significant correlation was observed between the levels of CRP or IL-6 and the duration of dialysis.Conclusions. In our study, we found high serum IL-6 and CRP levels in HCV-positive hemodialysis patients, compared with HCVnegative ones. However, we failed to show the significance of these differences. More studies with large sample sizes and evaluation of the other inflammatory markers are warranted.

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APA: Copy

AFZAL, NADEEM, SARWAR, ABBAS, AHMED, AZAZMAND, ARIF, MARIA, & JAVEED, KHURSHEED. (2011). EFFECT OF HEPATITIS C VIRUS ON C-REACTIVE PROTEIN AND INTERLEUKIN-6 IN HEMODIALYSIS PATIENTS. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 5(3), 182-186. SID. https://sid.ir/paper/309165/en

Vancouver: Copy

AFZAL NADEEM, SARWAR ABBAS, AHMED AZAZMAND, ARIF MARIA, JAVEED KHURSHEED. EFFECT OF HEPATITIS C VIRUS ON C-REACTIVE PROTEIN AND INTERLEUKIN-6 IN HEMODIALYSIS PATIENTS. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2011;5(3):182-186. Available from: https://sid.ir/paper/309165/en

IEEE: Copy

NADEEM AFZAL, ABBAS SARWAR, AZAZMAND AHMED, MARIA ARIF, and KHURSHEED JAVEED, “EFFECT OF HEPATITIS C VIRUS ON C-REACTIVE PROTEIN AND INTERLEUKIN-6 IN HEMODIALYSIS PATIENTS,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 5, no. 3, pp. 182–186, 2011, [Online]. Available: https://sid.ir/paper/309165/en

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