CHEMOKINE RECEPTOR 2-V64I AND CHEMOKINE RECEPTOR 5-Δ32 POLYMORPHISMS AND CLINICAL RISK FACTORS OF DELAYED GRAFT FUNCTION AND ACUTE REJECTION IN KIDNEY TRANSPLANTATION

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AZMANDIAN JALAL; MANDEGARY ALI; SABER AZADEH; TORSHABI MARYAM; ETMINAN ABBAS; EBADZADEH MOHAMMAD REZA; FAZELI FARAMARZ; SOLEYMANI SAMANEH; TAGHIPOUR ATEFEH; KARIMI MOHAMMAD ALI

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Journal: Iranian Journal of Kidney Diseases Year:2012 | Volume:6 | Issue:1 Page(s): 56-62

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Title

CHEMOKINE RECEPTOR 2-V64I AND CHEMOKINE RECEPTOR 5-Δ32 POLYMORPHISMS AND CLINICAL RISK FACTORS OF DELAYED GRAFT FUNCTION AND ACUTE REJECTION IN KIDNEY TRANSPLANTATION

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Keywords

CHEMOKINE RECEPTOR

GENETIC POLYMORPHISM

DELAYED GRAFT FUNCTION

GRAFT REJECTION

Abstract

Introduction: Chemokines and CHEMOKINE RECEPTORs have a pivotal role in immunity and inflammation. We aimed to evaluate their role in kidney transplant rejection.Materials and Methods: The association of chemokine (C-C motif) receptor 2 (CCR2)-V64I and CCR5-D32 gene polymorphisms with acute rejection (AR) and DELAYED GRAFT FUNCTION (DGF) were examined in 100 donor-recipient pairs. TheCCR2-V64I and CCR5-D32 alleles were determined using polymerase chain reaction and polymerase chain reaction-restriction fragment length polymorphism, respectively.Results: No associations were found between donors or recipients’ CCR2-V64Iand CCR5-D32 gene polymorphisms and AR or DGF.Of the characteristics of the donors, recipients, and transplantation, glomerulonephritis as a cause of kidney failure in the recipients was weakly associated with AR (relative risk, 6.1, 95% confidence interval, 0.8 to 46.0, P=0.07). Transplantation of kidney from females to males was weakly associated with DGF (relative risk, 5.5, 95% confidence interval, 0.9 to 33.0, P=0.06). There was a significant association between AR, but not DGF, and graft loss in the patients (relative risk, 28.6, 95% confidence interval, 1.7 to 487.0, P=0.03).Conclusions: Our study failed to suggest CCR2-V64I or CCR5-D32 gene polymorphisms as risk factors for AR and DGF in kidney transplantation. Sex-matching between donors and recipients should be considered for living donor kidney transplantation.

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APA: Copy

AZMANDIAN, JALAL, MANDEGARY, ALI, SABER, AZADEH, TORSHABI, MARYAM, ETMINAN, ABBAS, EBADZADEH, MOHAMMAD REZA, FAZELI, FARAMARZ, SOLEYMANI, SAMANEH, TAGHIPOUR, ATEFEH, & KARIMI, MOHAMMAD ALI. (2012). CHEMOKINE RECEPTOR 2-V64I AND CHEMOKINE RECEPTOR 5-Δ32 POLYMORPHISMS AND CLINICAL RISK FACTORS OF DELAYED GRAFT FUNCTION AND ACUTE REJECTION IN KIDNEY TRANSPLANTATION. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 6(1), 56-62. SID. https://sid.ir/paper/309313/en

Vancouver: Copy

AZMANDIAN JALAL, MANDEGARY ALI, SABER AZADEH, TORSHABI MARYAM, ETMINAN ABBAS, EBADZADEH MOHAMMAD REZA, FAZELI FARAMARZ, SOLEYMANI SAMANEH, TAGHIPOUR ATEFEH, KARIMI MOHAMMAD ALI. CHEMOKINE RECEPTOR 2-V64I AND CHEMOKINE RECEPTOR 5-Δ32 POLYMORPHISMS AND CLINICAL RISK FACTORS OF DELAYED GRAFT FUNCTION AND ACUTE REJECTION IN KIDNEY TRANSPLANTATION. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2012;6(1):56-62. Available from: https://sid.ir/paper/309313/en

IEEE: Copy

JALAL AZMANDIAN, ALI MANDEGARY, AZADEH SABER, MARYAM TORSHABI, ABBAS ETMINAN, MOHAMMAD REZA EBADZADEH, FARAMARZ FAZELI, SAMANEH SOLEYMANI, ATEFEH TAGHIPOUR, and MOHAMMAD ALI KARIMI, “CHEMOKINE RECEPTOR 2-V64I AND CHEMOKINE RECEPTOR 5-Δ32 POLYMORPHISMS AND CLINICAL RISK FACTORS OF DELAYED GRAFT FUNCTION AND ACUTE REJECTION IN KIDNEY TRANSPLANTATION,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 6, no. 1, pp. 56–62, 2012, [Online]. Available: https://sid.ir/paper/309313/en

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