CLOXACILLIN AS AN ANTIBIOTIC LOCK SOLUTION FOR PREVENTION OF CATHETER-ASSOCIATED INFECTION

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DAVANIPUR MOZHGAN; PAKFETRAT MARYAM; ROOZBEH JAMSHID

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Journal: Iranian Journal of Kidney Diseases Year:2011 | Volume:5 | Issue:5 Page(s): 328-331

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Title

CLOXACILLIN AS AN ANTIBIOTIC LOCK SOLUTION FOR PREVENTION OF CATHETER-ASSOCIATED INFECTION

Author(s)

DAVANIPUR MOZHGAN | PAKFETRAT MARYAM | ROOZBEH JAMSHID | Issue Writer Certificate

Keywords

CATHETER-RELATED INFECTIONS

BACTEREMIA

HEMODIALYSIS

CLOXACILLIN

Abstract

Introduction: Catheter-related infection is associated with increased all-cause mortality and morbidity in HEMODIALYSIS patients. This study aimed to evaluate an antimicrobial lock solution (cloxacillin and heparin) in temporary noncuffed double-lumen catheters for long-term intermittent HEMODIALYSIS as a method of preventing catheter-related infection.Materials and Methods: Patients on HEMODIALYSIS with noncuffed temporary double lumen catheter were randomly divided into 2 groups. Fifty patients received a solution containing CLOXACILLIN, 100 mg/mL, plus heparin, 1000 IU/mL as a 2.5-mL solution instilled in each of catheter lumens after dialysis session. Another 50 patients received only heparin. They were allowed to dwell until the next session of dialysis.Results: One catheter-related BACTEREMIA was observed in the antibiotic group whereas catheter-related BACTEREMIA was observed in 8 of those who received heparin only. The rate of catheterrelated BACTEREMIA episodes were 0.5 per 1000 catheter-days in the antibiotic group versus 7.8 per 1000 catheter-days in the control group (P=0.02).Conclusions: In the present study, application of CLOXACILLIN as antibiotic lock solution for dialysis catheters resulted in a considerable reduction in catheter-related BACTEREMIA rate.

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APA: Copy

DAVANIPUR, MOZHGAN, PAKFETRAT, MARYAM, & ROOZBEH, JAMSHID. (2011). CLOXACILLIN AS AN ANTIBIOTIC LOCK SOLUTION FOR PREVENTION OF CATHETER-ASSOCIATED INFECTION. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 5(5), 328-331. SID. https://sid.ir/paper/309347/en

Vancouver: Copy

DAVANIPUR MOZHGAN, PAKFETRAT MARYAM, ROOZBEH JAMSHID. CLOXACILLIN AS AN ANTIBIOTIC LOCK SOLUTION FOR PREVENTION OF CATHETER-ASSOCIATED INFECTION. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2011;5(5):328-331. Available from: https://sid.ir/paper/309347/en

IEEE: Copy

MOZHGAN DAVANIPUR, MARYAM PAKFETRAT, and JAMSHID ROOZBEH, “CLOXACILLIN AS AN ANTIBIOTIC LOCK SOLUTION FOR PREVENTION OF CATHETER-ASSOCIATED INFECTION,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 5, no. 5, pp. 328–331, 2011, [Online]. Available: https://sid.ir/paper/309347/en

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