مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

486
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

280
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

PROTECTIVE EFFECTS OF HYDROALCOHOLIC EXTRACT OF FERULAGO ANGULATA AGAINST GENTAMICIN-INDUCED NEPHROTOXICITY IN RATS

Pages

  189-196

Abstract

 Introduction.Gentamicin can lead to acute tubular injury and kidney dysfunction. This study aimed to evaluate the effect of Ferulago angulataon kidney function and other markers in rats with GENTAMICIN-induced NEPHROTOXICITY.Materials and Methods.Forty-eight male Wistar rats were divided into the following groups: group 1, the controls; group 2, rats receiving GENTAMICIN (120 mg/kg body weight per day, intraperitoneal) for 7 days without treatment; groups 3, 4 and 5, rats receiving GENTAMICIN for 7 days and oral treatment with 200 mg/kg, 400 mg/kg, and 800 mg/kg body weight per day of FERULAGO ANGULATEextract, respectively. Measurements included serum levels of creatinine, urea, uric acid, lipids, ferric-reducing antioxidant power, and protein carbonyl; kidney and serum levels of malondialdehyde; and serum and renal levels of tumor necrosis factor-a. Histopathology of kidney tissue was examined as well as renal catalase, superoxide dismutase, and vitamin C.Results.Compared to treatment with GENTAMICIN only, treatment withFerulago angulata resulted in a significantly higher high-density lipoprotein cholesterol, ferric-reducing antioxidant plasma, renal catalase, superoxide dismutase, and vitamin C levels. It was also associated with significantly lower serum levels of creatinine, urea, uric acid, malondialdehyde, protein carbonyl, tumor necrosis factor-a, total cholesterol, triglyceride, low-density lipoprotein cholesterol, and very low-density lipoprotein cholesterol.FERULAGO ANGULATEwas linked with a lower renal gene expression of tumor necrosis factor-a.Conclusions.The present study suggests that FERULAGO ANGULATE extract has protective effects against NEPHROTOXICITY due to GENTAMICIN.

Cites

References

  • No record.

    • Cite

    APA: Copy

    VALIPOUR, PARISA, HEIDARIAN, ESFANDIAR, KHOSHDEL, ABOLFAZL, & GHOLAMI ARJENAKI, MOSTAFA. (2016). PROTECTIVE EFFECTS OF HYDROALCOHOLIC EXTRACT OF FERULAGO ANGULATA AGAINST GENTAMICIN-INDUCED NEPHROTOXICITY IN RATS. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 10(4), 189-196. SID. https://sid.ir/paper/309495/en

    Vancouver: Copy

    VALIPOUR PARISA, HEIDARIAN ESFANDIAR, KHOSHDEL ABOLFAZL, GHOLAMI ARJENAKI MOSTAFA. PROTECTIVE EFFECTS OF HYDROALCOHOLIC EXTRACT OF FERULAGO ANGULATA AGAINST GENTAMICIN-INDUCED NEPHROTOXICITY IN RATS. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2016;10(4):189-196. Available from: https://sid.ir/paper/309495/en

    IEEE: Copy

    PARISA VALIPOUR, ESFANDIAR HEIDARIAN, ABOLFAZL KHOSHDEL, and MOSTAFA GHOLAMI ARJENAKI, “PROTECTIVE EFFECTS OF HYDROALCOHOLIC EXTRACT OF FERULAGO ANGULATA AGAINST GENTAMICIN-INDUCED NEPHROTOXICITY IN RATS,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 10, no. 4, pp. 189–196, 2016, [Online]. Available: https://sid.ir/paper/309495/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button