Diagnostic Urinary Proteome Profile for Immunoglobulin A Nephropathy

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SAMAVAT SHIVA; KALANTARI SHIVA; Rutishauser Dorothea; REZAEI TAVIRANI MOSTAFA; Parvin Mahmud; Zubarev Roman A

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Kidney Diseases Year:2015 | Volume:9 | Issue:3 Page(s): 239-248

Download Full-Text

View:

210

Download:

126

Cites:

Information Journal Paper

Title

Diagnostic Urinary Proteome Profile for Immunoglobulin A Nephropathy

Author(s)

Keywords

IgA glomerulonephritis

urine

proteomics

mass spectrometry

Abstract

Introduction. Immunoglobulin A (IgA) nephropathy, the most common type of glomerulonephritis, is only diagnosed by invasive kidney biopsy. urine proteome panel might help in noninvasive diagnosis and also better understanding of pathogenesis of IgA nephropathy. Materials and Methods. Second mid-stream urine samples of 13 patients with biopsy-proven IgA nephropathy and 8 healthy controls were investigated by means of nanoscale liquid chromatography tandem mass spectrometry. Multivariate analysis of quantified label-free proteins was performed by the principal component analysis and partial least squares models. Results. A total number of 493 unique proteins were quantified by nanoscale liquid chromatography tandem mass spectrometry, of which 46 proteins were considered as putative biomarkers of IgA nephropathy, after multivariate analysis and additional filter criterion and comparing the patients and the controls. Some of the significant differentially expressed proteins were CD44, glycoprotein 2, vasorin, epidermal growth factor, CLM9, protocadherin, utreoglobin, dipeptidyl peptidase IV, NHL repeat-containing protein 3, and SLAM family member 5. These proteins were related to various involved pathogenic pathways of inflammatory response and complement system. Conclusions. This proteome profile could be utilized in the diagnosis of IgA nephropathy. In addition, providing a noninvasive diagnostic tool, it may shed light on the pathogenesis of IgA nephropathy.

Cites

No record.

References

No record.

Cite

APA: Copy

SAMAVAT, SHIVA, KALANTARI, SHIVA, Rutishauser, Dorothea, REZAEI TAVIRANI, MOSTAFA, Parvin, Mahmud, & Zubarev, Roman A. (2015). Diagnostic Urinary Proteome Profile for Immunoglobulin A Nephropathy. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 9(3), 239-248. SID. https://sid.ir/paper/309534/en

Vancouver: Copy

SAMAVAT SHIVA, KALANTARI SHIVA, Rutishauser Dorothea, REZAEI TAVIRANI MOSTAFA, Parvin Mahmud, Zubarev Roman A. Diagnostic Urinary Proteome Profile for Immunoglobulin A Nephropathy. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2015;9(3):239-248. Available from: https://sid.ir/paper/309534/en

IEEE: Copy

SHIVA SAMAVAT, SHIVA KALANTARI, Dorothea Rutishauser, MOSTAFA REZAEI TAVIRANI, Mahmud Parvin, and Roman A Zubarev, “Diagnostic Urinary Proteome Profile for Immunoglobulin A Nephropathy,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 9, no. 3, pp. 239–248, 2015, [Online]. Available: https://sid.ir/paper/309534/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops