مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Oxidative Stress in Chronic Kidney Disease (Review)

Pages

  165-179

Abstract

 Patients with chronic kidney disease (CKD) have high incidence rates of cardiovascular disease and malignancy. Several factors contribute to these conditions. Structural characteristics in CKD, loss of renal energy, and uremia result in an imbalance between free radical production and antioxidant defenses. Also, CKD patients usually have multiple cardiovascular risk factors like diabetes mellitus, dyslipidemia, and hypertension. These conditions are associated with oxidative stress, which can trigger the inflammatory process and accelerate renal injury progression. There are some clinical biomarkers to detect oxidative stress and antioxidant status in CKD patients. Antioxidant therapies may be beneficial in reducing oxidative stress, lowering uremic cardiovascular toxicity, and improving survival. Therefore, their roles in CKD patients have been evaluated in several studies as a new target for therapeutic intervention. This review provides an overview of oxidative stress mechanisms, clinical squeals, biomarkers, and possible antioxidant therapies in CKD patients.

Cites

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    • Cite

    APA: Copy

    MODARESI, Atieh, NAFAR, M., & SAHRAEI, ZAHRA. (2015). Oxidative Stress in Chronic Kidney Disease (Review). IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 9(3), 165-179. SID. https://sid.ir/paper/309539/en

    Vancouver: Copy

    MODARESI Atieh, NAFAR M., SAHRAEI ZAHRA. Oxidative Stress in Chronic Kidney Disease (Review). IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2015;9(3):165-179. Available from: https://sid.ir/paper/309539/en

    IEEE: Copy

    Atieh MODARESI, M. NAFAR, and ZAHRA SAHRAEI, “Oxidative Stress in Chronic Kidney Disease (Review),” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 9, no. 3, pp. 165–179, 2015, [Online]. Available: https://sid.ir/paper/309539/en

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