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Information Journal Paper

Title

EFFECTS OF FLAXSEED OIL ON SERUM BONE TURNOVER MARKERS IN HEMODIALYSIS PATIENTS A RANDOMIZED CONTROLLED TRIAL

Pages

  215-222

Abstract

 Introduction: Chronic kidney disease-mineral and bone disorder is a common complication in HEMODIALYSIS patients. The present study was designed to investigate the effects of FLAXSEED OIL, a rich source of plant omega-3 fatty acid alpha-linolenic acid, on serum markers of bone formation and resorption in HEMODIALYSIS patients.Materials and Methods: In this randomized controlled trial, 34 HEMODIALYSIS patients were randomly assigned to either the FLAXSEED OIL or the control group. The patients in the FLAXSEED OIL group received 6 g/d of FLAXSEED OIL for 8 weeks, whereas the control group received 6 g/d of medium chain triglycerides oil. At baseline and the end of the 8th week, 7 mL of blood was obtained from each patient after a 12- to 14-hour fast and serum concentrations of OSTEOCALCIN, OSTEOPROTEGERIN, N-TELOPEPTIDE, and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B LIGAND were measured.Results: Serum N-TELOPEPTIDE concentration decreased significantly up to 17% in the FLAXSEED OIL group at the end of week 8, as compared to baseline (P<.01), and the reduction was significant in comparison with the control group. There were no significant differences between the two groups in the mean changes of serum OSTEOCALCIN, OSTEOPROTEGERIN, or RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B LIGAND.Conclusions: This study indicates that daily consumption of 6 g/d of FLAXSEED OIL may reduce bone resorption in HEMODIALYSIS patients.

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    APA: Copy

    MIRFATAHI, MARYAM, IMANI, HOSSEIN, TABIBI, HADI, NASROLLAHI, ALIREZA, & HEDAYATI, MEHDI. (2018). EFFECTS OF FLAXSEED OIL ON SERUM BONE TURNOVER MARKERS IN HEMODIALYSIS PATIENTS A RANDOMIZED CONTROLLED TRIAL. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 12(4), 215-222. SID. https://sid.ir/paper/309565/en

    Vancouver: Copy

    MIRFATAHI MARYAM, IMANI HOSSEIN, TABIBI HADI, NASROLLAHI ALIREZA, HEDAYATI MEHDI. EFFECTS OF FLAXSEED OIL ON SERUM BONE TURNOVER MARKERS IN HEMODIALYSIS PATIENTS A RANDOMIZED CONTROLLED TRIAL. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2018;12(4):215-222. Available from: https://sid.ir/paper/309565/en

    IEEE: Copy

    MARYAM MIRFATAHI, HOSSEIN IMANI, HADI TABIBI, ALIREZA NASROLLAHI, and MEHDI HEDAYATI, “EFFECTS OF FLAXSEED OIL ON SERUM BONE TURNOVER MARKERS IN HEMODIALYSIS PATIENTS A RANDOMIZED CONTROLLED TRIAL,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 12, no. 4, pp. 215–222, 2018, [Online]. Available: https://sid.ir/paper/309565/en

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