EFFICACY AND SAFETY OF RITUXIMAB IN CHILDREN WITH STEROIDAND CYCLOSPORINE-RESISTANT AND STEROID- AND CYCLOSPORINEDEPENDENT NEPHROTIC SYNDROME

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HOSEINI ROZITA; SABZIAN KAMRAN; OTUKESH HASAN; ZAFARANLOO NAZANIN; PANAHI PARSA; RAHIMZADEH NAHID; NAKHIEE SHAHRBANOO; AKHAVAN SEPEHI MOHSEN

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Journal: Iranian Journal of Kidney Diseases Year:2018 | Volume:12 | Issue:1 Page(s): 27-32

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Title

EFFICACY AND SAFETY OF RITUXIMAB IN CHILDREN WITH STEROIDAND CYCLOSPORINE-RESISTANT AND STEROID- AND CYCLOSPORINEDEPENDENT NEPHROTIC SYNDROME

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Keywords

NEPHROTIC SYNDROME

STEROID RESISTANCE

CYCLOSPORINE RESISTANCE

RITUXIMAB

CHILD

Abstract

Introduction: There is evidence of the effectiveness of RITUXIMAB in treatment of NEPHROTIC SYNDROME in CHILDren. The present study aimed to assess safety and the therapeutic effectiveness of RITUXIMAB in steroid- and cyclosporine-resistant pediatric NEPHROTIC SYNDROME.Materials and Methods: Forty-three CHILDren with steroid- and cyclosporine-resistant or steroid- and cyclosporine-dependent noncongenital NEPHROTIC SYNDROME were included in the study to receive intravenous RITUXIMAB, 375 mg/m2/wk, for 4 weeks. The CHILDren were followed up for 2 years. Effectiveness was defined as remission of proteinuria in response to RITUXIMAB. Side effects of RITUXIMAB were monitored.Results: Overall, 23 (57.1%) of the CHILDren had steroid- and cyclosporine-resistant NEPHROTIC SYNDROME, of whom 8 (34.8%) revealed complete response and 3 (13%) revealed partial response. Seven CHILDren (16.7%) had late-resistant NEPHROTIC SYNDROME, of whom 6 (85.7%) revealed complete response and none revealed partial response. Ten CHILDren (26.2%) had steroid- and cyclosporine dependence all of whom revealed complete response to RITUXIMAB. Complete response rate was significantly higher in those with drug dependent pattern than the other groups (P=.002). There was no association between response to RITUXIMAB and pathological basis of disease. Side effects were found in 4 patients as leukopenia in 2, alopecia in 1, and eosinophilia in 1.Conclusions: RITUXIMAB is effective for CHILDren with NEPHROTIC SYNDROME with high efficacy and well tolerability, especially in those with steroid- and cyclosporine-dependent NEPHROTIC SYNDROME.

Cites

Non-Nephrotic Proteinuria in Children: A Review

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APA: Copy

HOSEINI, ROZITA, SABZIAN, KAMRAN, OTUKESH, HASAN, ZAFARANLOO, NAZANIN, PANAHI, PARSA, RAHIMZADEH, NAHID, NAKHIEE, SHAHRBANOO, & AKHAVAN SEPEHI, MOHSEN. (2018). EFFICACY AND SAFETY OF RITUXIMAB IN CHILDREN WITH STEROIDAND CYCLOSPORINE-RESISTANT AND STEROID- AND CYCLOSPORINEDEPENDENT NEPHROTIC SYNDROME. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 12(1), 27-32. SID. https://sid.ir/paper/309585/en

Vancouver: Copy

HOSEINI ROZITA, SABZIAN KAMRAN, OTUKESH HASAN, ZAFARANLOO NAZANIN, PANAHI PARSA, RAHIMZADEH NAHID, NAKHIEE SHAHRBANOO, AKHAVAN SEPEHI MOHSEN. EFFICACY AND SAFETY OF RITUXIMAB IN CHILDREN WITH STEROIDAND CYCLOSPORINE-RESISTANT AND STEROID- AND CYCLOSPORINEDEPENDENT NEPHROTIC SYNDROME. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2018;12(1):27-32. Available from: https://sid.ir/paper/309585/en

IEEE: Copy

ROZITA HOSEINI, KAMRAN SABZIAN, HASAN OTUKESH, NAZANIN ZAFARANLOO, PARSA PANAHI, NAHID RAHIMZADEH, SHAHRBANOO NAKHIEE, and MOHSEN AKHAVAN SEPEHI, “EFFICACY AND SAFETY OF RITUXIMAB IN CHILDREN WITH STEROIDAND CYCLOSPORINE-RESISTANT AND STEROID- AND CYCLOSPORINEDEPENDENT NEPHROTIC SYNDROME,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 12, no. 1, pp. 27–32, 2018, [Online]. Available: https://sid.ir/paper/309585/en

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