THE EFFECTS OF DIFFERENT DOSES OF SCORPION (ODONBUTHUS) VENOM ON SOME CHANGES OF BIOCHEMICAL FACTORS OF BLOOD SERUM IN DOGS

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JAFARI SHOURIJEH S.; KHAMESIPOUR V.R.

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Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2001 | Volume:8 | Issue:35 Page(s): 15-24

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Title

THE EFFECTS OF DIFFERENT DOSES OF SCORPION (ODONBUTHUS) VENOM ON SOME CHANGES OF BIOCHEMICAL FACTORS OF BLOOD SERUM IN DOGS

Author(s)

JAFARI SHOURIJEH S. | KHAMESIPOUR V.R. | Issue Writer Certificate

Keywords

VENOMQ3

ODONTOBUTHUYQ4

SERUM BIOCHEMICAL FACTORSQ4

DOGQ3

Abstract

Sixteen healthy native DOGs aged about 2, with average body weight of 18.5 kg, of both sexes were divided randomly into four groups. Blood samples were collected for laboratory examination. before infection of the VENOM. In the control group, 1 ml of saline solution was injected to each DOG of the group; the amounts of equal to 0.1, 0.05 and 0.01 mg of VENOM powder per kg of body weight were dissolved in 1 ml saline solution and injected interadermaly in the abdominal region or hind limb of each DOG in the second, third and fourth groups respectively. Blood samples were collected at different time intervals (5,13,30,60,90 minutes and 2,3,6 and 24 hours) after the injection of VENOM and laboratory examinations (Glucose, AST, ALT, ALP, CK, LDH, BUN, Creating and BUN/Creatinin) were done on the serum samples and finally the results were .analyzed by statistical methods. The results of the analysis showed a significant increase in the amounts of the glucose, AST, ALT, ALP, CK after the injection of the serum. (P< 0.05). Results of the study indicated that biochemical changes of serum in DOGs lead to hepatocellular degeneration and necrosis, homeostasis, cardiac and pulmonary infarction, and pancreatitis. The fin dingy of the present study suggest that there may exist hepatotoxic and cardio toxic factor/factors in the VENOM of this type of scorpion.

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APA: Copy

JAFARI SHOURIJEH, S., & KHAMESIPOUR, V.R.. (2001). THE EFFECTS OF DIFFERENT DOSES OF SCORPION (ODONBUTHUS) VENOM ON SOME CHANGES OF BIOCHEMICAL FACTORS OF BLOOD SERUM IN DOGS. DANESHVAR MEDICINE, 8(35), 15-24. SID. https://sid.ir/paper/31089/en

Vancouver: Copy

JAFARI SHOURIJEH S., KHAMESIPOUR V.R.. THE EFFECTS OF DIFFERENT DOSES OF SCORPION (ODONBUTHUS) VENOM ON SOME CHANGES OF BIOCHEMICAL FACTORS OF BLOOD SERUM IN DOGS. DANESHVAR MEDICINE[Internet]. 2001;8(35):15-24. Available from: https://sid.ir/paper/31089/en

IEEE: Copy

S. JAFARI SHOURIJEH, and V.R. KHAMESIPOUR, “THE EFFECTS OF DIFFERENT DOSES OF SCORPION (ODONBUTHUS) VENOM ON SOME CHANGES OF BIOCHEMICAL FACTORS OF BLOOD SERUM IN DOGS,” DANESHVAR MEDICINE, vol. 8, no. 35, pp. 15–24, 2001, [Online]. Available: https://sid.ir/paper/31089/en

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