TOPICAL STEROIDS FOR PREVENTION OF DIFFUSE LAMELLAR KERATITIS FOLLOWING LASIK

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KARIMIAN FARID; YOURDKHANI H.; ANISIAN A.; MOHAMMADPOUR M.; YAZDANI SHAHIN

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Journal: Journal of Ophthalmic and Vision Research Year:2007 | Volume:2 | Issue:2 Page(s): 119-123

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Title

TOPICAL STEROIDS FOR PREVENTION OF DIFFUSE LAMELLAR KERATITIS FOLLOWING LASIK

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Abstract

Purpose: To determine the role of prophylactic topical steroids in the prevention of diffuse lamellar keratitis (DLK) after laser in situ keratomileusis (LASIK).Methods: This randomized double blind clinical trial included consecutive LASIK candidates aged 18 to 55 years with stable (³1 year) myopia ranging from -2 to -12 diopters. The day before surgery, eyes were randomly allocated to topical betamethasone 0.1% or placebo every four hours. One hour preoperatively, the dosage was increased to every five minutes for at least six times. DLK was graded according to the Linebarger- Lindstorm classification. Patients were examined one week and one and three months after surgery. Best-corrected visual acuity (BCVA), manifest and cycloplegic refraction and severity of DLK were documented at each visit by a masked examiner.Results: Overall, 198 eyes (100 in the treatment group and 98 in the control group) of 101 patients (97 bilateral and 4 unilateral cases) were operated. Pre- and post-LASIK refraction and BCVA were comparable in the study groups (P> 0.05). There were no significant complications in either group during or after LASIK except for DLK which developed in 55 eyes (55%) of the treatment group including 44 eyes with grade I and 11 eyes with grade II, versus 36 eyes (36.7%) of the control group including 29 eyes with grade I and 7 eyes with grade II DLK (P= 0.81).Conclusion: Although steroids play a key role in the treatment of DLK, pretreatment with topical steroids 24 hours prior to LASIK does not seem prevent this complication.

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THE EFFICACY OF HOURLY PROPHYLACTIC STEROIDS IN EPIDEMIC DIFFUSE LAMELLAR KERATITIS

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APA: Copy

KARIMIAN, FARID, YOURDKHANI, H., ANISIAN, A., MOHAMMADPOUR, M., & YAZDANI, SHAHIN. (2007). TOPICAL STEROIDS FOR PREVENTION OF DIFFUSE LAMELLAR KERATITIS FOLLOWING LASIK. JOURNAL OF OPHTHALMIC AND VISION RESEARCH, 2(2), 119-123. SID. https://sid.ir/paper/311314/en

Vancouver: Copy

KARIMIAN FARID, YOURDKHANI H., ANISIAN A., MOHAMMADPOUR M., YAZDANI SHAHIN. TOPICAL STEROIDS FOR PREVENTION OF DIFFUSE LAMELLAR KERATITIS FOLLOWING LASIK. JOURNAL OF OPHTHALMIC AND VISION RESEARCH[Internet]. 2007;2(2):119-123. Available from: https://sid.ir/paper/311314/en

IEEE: Copy

FARID KARIMIAN, H. YOURDKHANI, A. ANISIAN, M. MOHAMMADPOUR, and SHAHIN YAZDANI, “TOPICAL STEROIDS FOR PREVENTION OF DIFFUSE LAMELLAR KERATITIS FOLLOWING LASIK,” JOURNAL OF OPHTHALMIC AND VISION RESEARCH, vol. 2, no. 2, pp. 119–123, 2007, [Online]. Available: https://sid.ir/paper/311314/en

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