PROPHYLACTIC EFFECTS OF MITOMYCIN-C ON REGRESSION AND HAZE FORMATION IN PHOTOREFRACTIVE KERATECTOMY

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HASHEMI HASAN; TAHERI M.R.; FOTOUHI A.

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Journal: Journal of Ophthalmic and Vision Research Year:2006 | Volume:1 | Issue:1 Page(s): 0-0

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Title

PROPHYLACTIC EFFECTS OF MITOMYCIN-C ON REGRESSION AND HAZE FORMATION IN PHOTOREFRACTIVE KERATECTOMY

Author(s)

HASHEMI HASAN | TAHERI M.R. | FOTOUHI A. | Issue Writer Certificate

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Abstract

Purpose: To study the effect of prophylactic application of mitomycin-C on regression and corneal haze formation after photorefractive keratectomy (PRK) for high myopia.Methods: Fifty-four eyes of 28 high myopic patients were enrolled in this prospective study. All eyes underwent PRK with application of 0.02% mitomycin-C for two minutes and irrigation with 15-20 ml of normal saline. Follow-up visits were scheduled for the first 7 days and 1,3 and 6 months after surgery. Hanna grading (in the scale of 0 to 4+) was used to assess corneal haze.Results: Mean spherical equivalent refraction (SE) was -7.08 ± 1.11 diopters (D), preoperatively. All eyes were examined on the first 7 days and one month after surgery; 48 eyes (88.9%) were evaluated 3 and 6 months post-surgery. Six months after surgery, all eyes had uncorrected visual acuity (UCVA) of 20/40 or better and 37 eyes (77.1 %) achieved UCVA of 20/20 or better, 45 eyes (93.7%) had SE within ±1.00D of emmetropia. One month postoperatively, 2 eyes (3.7%) had grade 0.5 haze, while at 3 and 6 months after surgery no visited eye had haze at all. There was no decrease in best corrected visual acuity after 6 months. In spatial frequencies of 6 and 12 cycle/degree, contrast sensitivity decreased immediately after PRK but increased to the preoperative values by the 6th postoperative month.Conclusions: Mitomycin-C can prevent the development of corneal haze when treating high myopia with PRK. In patients with insufficient corneal thickness for laser in situ keratomileusis (LASIK), mitomycin-C makes a useful adjunct to PRK to provide an alternative treatment for myopia. However, further research with longer follow-up is suggested.

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APA: Copy

HASHEMI, HASAN, TAHERI, M.R., & FOTOUHI, A.. (2006). PROPHYLACTIC EFFECTS OF MITOMYCIN-C ON REGRESSION AND HAZE FORMATION IN PHOTOREFRACTIVE KERATECTOMY. JOURNAL OF OPHTHALMIC AND VISION RESEARCH, 1(1), 0-0. SID. https://sid.ir/paper/311346/en

Vancouver: Copy

HASHEMI HASAN, TAHERI M.R., FOTOUHI A.. PROPHYLACTIC EFFECTS OF MITOMYCIN-C ON REGRESSION AND HAZE FORMATION IN PHOTOREFRACTIVE KERATECTOMY. JOURNAL OF OPHTHALMIC AND VISION RESEARCH[Internet]. 2006;1(1):0-0. Available from: https://sid.ir/paper/311346/en

IEEE: Copy

HASAN HASHEMI, M.R. TAHERI, and A. FOTOUHI, “PROPHYLACTIC EFFECTS OF MITOMYCIN-C ON REGRESSION AND HAZE FORMATION IN PHOTOREFRACTIVE KERATECTOMY,” JOURNAL OF OPHTHALMIC AND VISION RESEARCH, vol. 1, no. 1, pp. 0–0, 2006, [Online]. Available: https://sid.ir/paper/311346/en

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