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Information Journal Paper

Title

EXPLORING THE BASIS OF SEX BIAS IN PRIMARY CONGENITAL GLAUCOMA

Pages

  73-74

Keywords

Not Registered.

Abstract

 Singapore Eye Research Institute, Singapore National Eye Centre, Singapore Glaucoma, an optic neuropathy characterized by progressive visual field loss, is the leading cause of irreversible blindness worldwide. The condition has a substantial heritable basis, as illustrated by the numerous loci and genes identified to date and the large proportion of patients with positive family history. When glaucoma manifests before the age of 40 years, it tends to be more aggressive, more resistant to medical therapy and associated with more visual impairment. 1,2 This category includes congenital/infantile glaucoma which is a genetically heterogeneous group by itself with the involvement of one gene (CYP1B1) and at least two other genetic loci. 3-6 The only known gene for primary congenital glaucoma (PCG), CYP1B1, encodes cytochrome P4501B1 that is involved in the metabolism of many compounds, including the 4-hydroxylation of 17b -estradiol. 7 It has been hypothesized that alterations in the metabolism of estrogens may be the basis for ocular abnormalities associated with defects in this gene.

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    APA: Copy

    VITHANA, E.V., & AUNG, T.. (2009). EXPLORING THE BASIS OF SEX BIAS IN PRIMARY CONGENITAL GLAUCOMA. JOURNAL OF OPHTHALMIC AND VISION RESEARCH, 4(2), 73-74. SID. https://sid.ir/paper/311361/en

    Vancouver: Copy

    VITHANA E.V., AUNG T.. EXPLORING THE BASIS OF SEX BIAS IN PRIMARY CONGENITAL GLAUCOMA. JOURNAL OF OPHTHALMIC AND VISION RESEARCH[Internet]. 2009;4(2):73-74. Available from: https://sid.ir/paper/311361/en

    IEEE: Copy

    E.V. VITHANA, and T. AUNG, “EXPLORING THE BASIS OF SEX BIAS IN PRIMARY CONGENITAL GLAUCOMA,” JOURNAL OF OPHTHALMIC AND VISION RESEARCH, vol. 4, no. 2, pp. 73–74, 2009, [Online]. Available: https://sid.ir/paper/311361/en

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