SCREENING FOR MIR184 MUTATIONS IN IRANIAN PATIENTS WITH KERATOCONUS

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FARZADFARD AZAD; NASSIRI NADER; NEKUIE MOGHADAM TAYEBEH; PAYLAKHI SEYED HASSAN; ELAHI ELAHE

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Journal Paper

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Journal: Journal of Ophthalmic and Vision Research Year:2016 | Volume:11 | Issue:1 Page(s): 3-7

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Title

SCREENING FOR MIR184 MUTATIONS IN IRANIAN PATIENTS WITH KERATOCONUS

Author(s)

Keywords

MIR-184

KERATOCONUS

IRAN

Abstract

Purpose: To investigate whether microRNA (MIR) ‑184 mutations make a substantial contribution to KERATOCONUS (KCN) among affected IRANian patients.Methods: A total of 47 IRANian KCN patients, diagnosed based on family history, clinical examinations using slit lamp biomicroscopy, refraction and corneal topography were enrolled in this study. The pri‑miR‑184 encoding gene obtained from the DNAs of all participants was amplified using polymerase chain reaction and subsequently sequenced by the Sanger dideoxynucleotide protocol. The sequences were compared to MIR184 reference sequence in order to identify sequence variations. The potential effects of a single variation observed on RNA structure was predicted.Results: Only one sequence variation, +39G>T, was observed within the pri‑miR‑184 encoding sequence in one proband. The patient’s KCN‑affected sister harbored the same variation. The variation was not novel and was recently shown to be present at similar frequencies among large cohorts of KCN patients and control individuals.Conclusion: Mutations in MIR‑184 are not a major cause of KERATOCONUS among IRANian patients. The pri‑miR‑184 sequence needs to be screened in larger cohorts in order to establish whether mutations in the gene are present at low frequencies among IRANian patients.

Cites

KERATOCONUS, A TRUE CORNEAL DISEASE (EDITORIAL)

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APA: Copy

FARZADFARD, AZAD, NASSIRI, NADER, NEKUIE MOGHADAM, TAYEBEH, PAYLAKHI, SEYED HASSAN, & ELAHI, ELAHE. (2016). SCREENING FOR MIR184 MUTATIONS IN IRANIAN PATIENTS WITH KERATOCONUS. JOURNAL OF OPHTHALMIC AND VISION RESEARCH, 11(1), 3-7. SID. https://sid.ir/paper/311613/en

Vancouver: Copy

FARZADFARD AZAD, NASSIRI NADER, NEKUIE MOGHADAM TAYEBEH, PAYLAKHI SEYED HASSAN, ELAHI ELAHE. SCREENING FOR MIR184 MUTATIONS IN IRANIAN PATIENTS WITH KERATOCONUS. JOURNAL OF OPHTHALMIC AND VISION RESEARCH[Internet]. 2016;11(1):3-7. Available from: https://sid.ir/paper/311613/en

IEEE: Copy

AZAD FARZADFARD, NADER NASSIRI, TAYEBEH NEKUIE MOGHADAM, SEYED HASSAN PAYLAKHI, and ELAHE ELAHI, “SCREENING FOR MIR184 MUTATIONS IN IRANIAN PATIENTS WITH KERATOCONUS,” JOURNAL OF OPHTHALMIC AND VISION RESEARCH, vol. 11, no. 1, pp. 3–7, 2016, [Online]. Available: https://sid.ir/paper/311613/en

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