POPULATION PHARMACOKINETICS AND PHARMACOKINETIC-PHARMACODYNAMIC RELATIONSHIPS OF METHADONE IN A SAMPLE OF IRANIAN (MAZANDARANI) OPIATE USERS UNDERGOING METHADONE MAINTENANCE TREATMENT

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SHIRAN MOHAMMAD REZA; HOSSEINZADEH RASA; HAMIDIKENARI ABOLHASSAN; ZARGHAMI MEHRAN; LAMSEHCHI NARGESS; RAFATI MOHAMMAD REZA

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Journal Paper

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Journal: Iranian Journal of Psychiatry and Behavioral Sciences Year:2012 | Volume:5 | Issue:2 Page(s): 53-61

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Title

POPULATION PHARMACOKINETICS AND PHARMACOKINETIC-PHARMACODYNAMIC RELATIONSHIPS OF METHADONE IN A SAMPLE OF IRANIAN (MAZANDARANI) OPIATE USERS UNDERGOING METHADONE MAINTENANCE TREATMENT

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Keywords

IRANIAN

METHADONE

OPIATE USERS

PHARMACODYNAMICS

PHARMACOKINETICS

Abstract

Objective: To investigate the PHARMACOKINETICS (PK) and PK- pharmacodynamic (PD) relationship of METHADONE in a cohort of outpatients undergoing METHADONE maintenance treatment (MMT).Methods: Sixty male patients undergoing MMT with a mean ±SD METHADONE daily dosage of 58±34 mg were enrolled in this study. A 5-ml blood sample was collected before the daily intake of METHADONE. As a PD measure, the Subjective Opioid Withdrawal Scale (SOWS) form was completed immediately after obtaining the blood sample. Blood samples were taken and the forms were completed 4-5 times more (up to 24 hr) after the daily intake of METHADONE. Plasma METHADONE was analyzed using HPLC. Population PK/PD analysis was performed using population PHARMACOKINETICS modeling software P-Pharm.Results: Significant decreases (p<0.05) were observed in the SOWS scores during 10 hours after METHADONE intake. The SOWS had returned to baseline by 24 hr after using methaodone (p=0.98). A considerable interindividual variability in the CL/F (16 fold), EC50 (3 fold) and Emax (6 fold) for METHADONE was observed.Conclusion: Withdrawal symptoms were significantly improved in MMT patients after taking METHADONE and the PD measure was substantially affected by fluctuations in plasma METHADONE concentration. However, The SOWS had returned to baseline by 24 hr after using mathadone. Thus, a once daily dosing of METHADONE may not be suitable for those MMT patients who experience a significant withdrawal disturbance in the latter part of the interdose interval. This may increase the perceived severity of withdrawal and induce a craving for additional opioids.

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APA: Copy

SHIRAN, MOHAMMAD REZA, HOSSEINZADEH, RASA, HAMIDIKENARI, ABOLHASSAN, ZARGHAMI, MEHRAN, LAMSEHCHI, NARGESS, & RAFATI, MOHAMMAD REZA. (2012). POPULATION PHARMACOKINETICS AND PHARMACOKINETIC-PHARMACODYNAMIC RELATIONSHIPS OF METHADONE IN A SAMPLE OF IRANIAN (MAZANDARANI) OPIATE USERS UNDERGOING METHADONE MAINTENANCE TREATMENT. IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES (IJPBS), 5(2), 53-61. SID. https://sid.ir/paper/311934/en

Vancouver: Copy

SHIRAN MOHAMMAD REZA, HOSSEINZADEH RASA, HAMIDIKENARI ABOLHASSAN, ZARGHAMI MEHRAN, LAMSEHCHI NARGESS, RAFATI MOHAMMAD REZA. POPULATION PHARMACOKINETICS AND PHARMACOKINETIC-PHARMACODYNAMIC RELATIONSHIPS OF METHADONE IN A SAMPLE OF IRANIAN (MAZANDARANI) OPIATE USERS UNDERGOING METHADONE MAINTENANCE TREATMENT. IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES (IJPBS)[Internet]. 2012;5(2):53-61. Available from: https://sid.ir/paper/311934/en

IEEE: Copy

MOHAMMAD REZA SHIRAN, RASA HOSSEINZADEH, ABOLHASSAN HAMIDIKENARI, MEHRAN ZARGHAMI, NARGESS LAMSEHCHI, and MOHAMMAD REZA RAFATI, “POPULATION PHARMACOKINETICS AND PHARMACOKINETIC-PHARMACODYNAMIC RELATIONSHIPS OF METHADONE IN A SAMPLE OF IRANIAN (MAZANDARANI) OPIATE USERS UNDERGOING METHADONE MAINTENANCE TREATMENT,” IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES (IJPBS), vol. 5, no. 2, pp. 53–61, 2012, [Online]. Available: https://sid.ir/paper/311934/en

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