مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

LOSS OF P16 PROTEIN EXPRESSION AND ITS ASSOCIATION WITH EPSTEIN‐BARR VIRUS LMP-1 EXPRESSION IN HODGKIN'S LYMPHOMA

Pages

  78-84

Abstract

 Background: Expression of Epstein-Barr virus Latent Member Protein-1 (EBV LMP- 1) and loss of P16 protein expression are documented in LYMPHOMA, indicating a relationship between them, but this relationship is not clear and sometimes contradictory. Thus, this study was conducted to examine the relationship between the loss of P16 and EBV LMP-1 expression in Jordanian patients diagnosed with LYMPHOMA.Methods: Sections were made from archival formalin-fixed and paraffin embedded blocks from 55 patients diagnosed with LYMPHOMA. P16 expression and LMP-1 expression were detected by IMMUNOHISTOCHEMISTRY using MONOCLONAL ANTIBODIES.Results: In Hodgkin's LYMPHOMA (HL), the loss of P16 was higher in LMP-1 positive cases (61%) than LMP-1 negative cases (25%; P=0.072). Conversely, in Non- Hodgkin's LYMPHOMA (NHL), none of LMP-1 positive samples showed loss of P16.Furthermore, among LMP-1 HL positive cases, the loss of P16 was more frequent in male (75%) than female (33%). Also, there was a significantly higher proportion of LMP-1 positive cases showing loss of P16 in HL (11: 18), compared to those in NHL (0: 8, P<0.001), confirming a difference between HL and NHL, concerning the LMP-1/P16 relationship.Conclusion: A trend for an association between loss of P16 and LMP-1 expression was observed in HL but not NHL patients. These findings suggest that there are molecular and clinical differences in the pathogenesis and development of different subtypes of LYMPHOMA.

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    APA: Copy

    IRSHAID, FAWZI, TARAWNEH, KHALED, ALSHDEFAT, AISHA, DILMI, FATIHA, JARAN, ADNAN, AL-HADITHI, RAJI, & AL-KHATIB, AHAD. (2013). LOSS OF P16 PROTEIN EXPRESSION AND ITS ASSOCIATION WITH EPSTEIN‐BARR VIRUS LMP-1 EXPRESSION IN HODGKIN'S LYMPHOMA. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), 6(2), 78-84. SID. https://sid.ir/paper/312578/en

    Vancouver: Copy

    IRSHAID FAWZI, TARAWNEH KHALED, ALSHDEFAT AISHA, DILMI FATIHA, JARAN ADNAN, AL-HADITHI RAJI, AL-KHATIB AHAD. LOSS OF P16 PROTEIN EXPRESSION AND ITS ASSOCIATION WITH EPSTEIN‐BARR VIRUS LMP-1 EXPRESSION IN HODGKIN'S LYMPHOMA. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION)[Internet]. 2013;6(2):78-84. Available from: https://sid.ir/paper/312578/en

    IEEE: Copy

    FAWZI IRSHAID, KHALED TARAWNEH, AISHA ALSHDEFAT, FATIHA DILMI, ADNAN JARAN, RAJI AL-HADITHI, and AHAD AL-KHATIB, “LOSS OF P16 PROTEIN EXPRESSION AND ITS ASSOCIATION WITH EPSTEIN‐BARR VIRUS LMP-1 EXPRESSION IN HODGKIN'S LYMPHOMA,” INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), vol. 6, no. 2, pp. 78–84, 2013, [Online]. Available: https://sid.ir/paper/312578/en

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