TREATMENT OUTCOMES AND PROGNOSTIC FACTORS IN PEDIATRIC NON-BRAINSTEM ASTROCYTOMA IN NORTH EAST OF IRAN

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ANVARI KAZEM; SEILANIAN TOUSSI MEHDI; BAHADORKHAN GHOLAMREZA; BITAGHSIR MOTAHARE; HEIDARI MOZHGAN; FAZL ERSI MITRA; SHAHIDSALES SOODABEH

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Journal: International Journal of Cancer Management Year:2014 | Volume:7 | Issue:2 Page(s): 96-100

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Title

TREATMENT OUTCOMES AND PROGNOSTIC FACTORS IN PEDIATRIC NON-BRAINSTEM ASTROCYTOMA IN NORTH EAST OF IRAN

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Keywords

PEDIATRIC

NON-BRAIN STEM

ASTROCYTOMA

Abstract

Background: Central Nervous System (CNS) tumors have accounted for approximately one fourth of all PEDIATRIC malignancies. CNS tumors have been the most common solid malignancies among the children. In this study, we have evaluated survival and prognostic factors in children with NON-BRAIN STEM ASTROCYTOMA.Methods: Children with NON-BRAIN STEM ASTROCYTOMA, referring to radiation oncology centers of Ghaem and Omid hospitals of Mashhad, have included in this retrospective study, in years 2000-2010. Patients’ demographic data, past medical history, clinical symptoms, extent of tumor resection and treatment modality have recorded. Disease-free survival and overall survival have measured using Kaplan-Meier method.Results: We studied 87 patients with male to female ratio of 44.43 (1.02), and median age of 10 yrs (range: 2-15 yrs). Tumor grade distribution was as follows: grade I: 20 (23%) subjects; grade II: 34 (39.1%) subjects; grade III: 20 (23%) subjects; and grade IV: 13 (14.9%) subjects. The median follow-up duration was 38 months (6 to 110), and 16 months (4 to 100) for patients with low- and high-grade tumors. The 2-year survival rates in grades I-IV were 100%, 84.7%, 60% and 10.8%, respectively. Tumor resection less than gross total and non-ambulation have associated with a significantly inferior survival in both groups multivariate analysis, with high- and low-grade tumors.Conclusion: For all the cases of the PEDIATRIC non-brainstem ASTROCYTOMA, tumor grade had dramatic influences on their survival. Performing gross total resection was crucial for achieving favorable outcomes in both low-grade and high-grade cases. Moreover, according to the results, having major motor deficits has associated with lower survival.

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APA: Copy

ANVARI, KAZEM, SEILANIAN TOUSSI, MEHDI, BAHADORKHAN, GHOLAMREZA, BITAGHSIR, MOTAHARE, HEIDARI, MOZHGAN, FAZL ERSI, MITRA, & SHAHIDSALES, SOODABEH. (2014). TREATMENT OUTCOMES AND PROGNOSTIC FACTORS IN PEDIATRIC NON-BRAINSTEM ASTROCYTOMA IN NORTH EAST OF IRAN. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), 7(2), 96-100. SID. https://sid.ir/paper/312603/en

Vancouver: Copy

ANVARI KAZEM, SEILANIAN TOUSSI MEHDI, BAHADORKHAN GHOLAMREZA, BITAGHSIR MOTAHARE, HEIDARI MOZHGAN, FAZL ERSI MITRA, SHAHIDSALES SOODABEH. TREATMENT OUTCOMES AND PROGNOSTIC FACTORS IN PEDIATRIC NON-BRAINSTEM ASTROCYTOMA IN NORTH EAST OF IRAN. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION)[Internet]. 2014;7(2):96-100. Available from: https://sid.ir/paper/312603/en

IEEE: Copy

KAZEM ANVARI, MEHDI SEILANIAN TOUSSI, GHOLAMREZA BAHADORKHAN, MOTAHARE BITAGHSIR, MOZHGAN HEIDARI, MITRA FAZL ERSI, and SOODABEH SHAHIDSALES, “TREATMENT OUTCOMES AND PROGNOSTIC FACTORS IN PEDIATRIC NON-BRAINSTEM ASTROCYTOMA IN NORTH EAST OF IRAN,” INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), vol. 7, no. 2, pp. 96–100, 2014, [Online]. Available: https://sid.ir/paper/312603/en

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