THE STUDY OF “DIHYDROPYRIMIDINASE RELATED PROTEINS (DRPS)” EXPRESSION CHANGES INFLUENCE IN MALIGNANT ASTROCYTOMA BRAIN TUMOR

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POOLADI MEHDI; REZAEI TAVIRANI MOSTAFA; HASHEMI MEHRDAD; HESAMI TACKALLOU SAEED; KHAGHANI RAZI ABAD SOLMAZ; MORADI AFSHIN; ZALI ALIREZA; MOUSAVI MASOUMEA; RAKHSHAN AZADEH; FIROZI DALVAND LEILA; OMIDI ROGHAYE

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Journal Paper

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Journal: International Journal of Cancer Management Year:2014 | Volume:7 | Issue:3 Page(s): 130-136

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Title

THE STUDY OF “DIHYDROPYRIMIDINASE RELATED PROTEINS (DRPS)” EXPRESSION CHANGES INFLUENCE IN MALIGNANT ASTROCYTOMA BRAIN TUMOR

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Keywords

ASTEROCYTOMA

PROTEOMICS

DRP AND 2DG ELECTROPHORESIS

Abstract

Background: Dihydropyrimidinase Related Proteins (DRPs) have known homologous to the Collapsing Response Mediator Proteins (CRMPs). The DRP gene family has comprised four members, DRP 1, 2, 3, and 4, all out of which have considered to be involved in axonal outgrowth and path-finding.Methods: The protein has extracted from tumor, normal brain tissues, and then the protein purity has evaluated by Bradford test and spectrophotometric methods. In this study, proteins has separated by Two-Dimensional Gel (2DG) electrophoresis method and then spots have analyzed and compared using statistical data and specific software (Progenesis Same Spots).Spots have identified by pH isoelectric, molecular weights and data banks.Results: The 2D gel has shown 800 spots totally. Two spots have reported for DRP2, and one spot has reported for DRP3 in the human brain proteome, that have differed in pH isoelectric, and Molecular Weights values.Conclusion: This protein family has involved in neuronal differentiation and axonal guidance, and abundantly influenced in the developing brain, but their expression persisted into adulthood. DRP2 has regulated by phosphorylation, Glycogen synthase kinase 3, regulate phosphorylation of DRP2 an inactive from, and induced neuronal polarity.

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APA: Copy

POOLADI, MEHDI, REZAEI TAVIRANI, MOSTAFA, HASHEMI, MEHRDAD, HESAMI TACKALLOU, SAEED, KHAGHANI RAZI ABAD, SOLMAZ, MORADI, AFSHIN, ZALI, ALIREZA, MOUSAVI, MASOUMEA, RAKHSHAN, AZADEH, FIROZI DALVAND, LEILA, & OMIDI, ROGHAYE. (2014). THE STUDY OF “DIHYDROPYRIMIDINASE RELATED PROTEINS (DRPS)” EXPRESSION CHANGES INFLUENCE IN MALIGNANT ASTROCYTOMA BRAIN TUMOR. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), 7(3), 130-136. SID. https://sid.ir/paper/312622/en

Vancouver: Copy

POOLADI MEHDI, REZAEI TAVIRANI MOSTAFA, HASHEMI MEHRDAD, HESAMI TACKALLOU SAEED, KHAGHANI RAZI ABAD SOLMAZ, MORADI AFSHIN, ZALI ALIREZA, MOUSAVI MASOUMEA, RAKHSHAN AZADEH, FIROZI DALVAND LEILA, OMIDI ROGHAYE. THE STUDY OF “DIHYDROPYRIMIDINASE RELATED PROTEINS (DRPS)” EXPRESSION CHANGES INFLUENCE IN MALIGNANT ASTROCYTOMA BRAIN TUMOR. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION)[Internet]. 2014;7(3):130-136. Available from: https://sid.ir/paper/312622/en

IEEE: Copy

MEHDI POOLADI, MOSTAFA REZAEI TAVIRANI, MEHRDAD HASHEMI, SAEED HESAMI TACKALLOU, SOLMAZ KHAGHANI RAZI ABAD, AFSHIN MORADI, ALIREZA ZALI, MASOUMEA MOUSAVI, AZADEH RAKHSHAN, LEILA FIROZI DALVAND, and ROGHAYE OMIDI, “THE STUDY OF “DIHYDROPYRIMIDINASE RELATED PROTEINS (DRPS)” EXPRESSION CHANGES INFLUENCE IN MALIGNANT ASTROCYTOMA BRAIN TUMOR,” INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), vol. 7, no. 3, pp. 130–136, 2014, [Online]. Available: https://sid.ir/paper/312622/en

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