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Information Journal Paper

Title

THE EFFECTS OF AQUEOUS EXTRACT OF ALPINIA GALANGAL ON GASTRIC CANCER CELLS (AGS) AND L929 CELLS IN VITRO

Pages

  142-146

Keywords

AGS 
MTT 

Abstract

 Background: Although the incidence of gastric cancer is declining during the last half century, this cancer still is the second morbid cancer in the world after lung cancer. The incidence of gastric cancer is 26 per 100,000 in Iran. This study evaluated the effect of ALPINIA GALANGAL on AGS cells (human gastric adenocarcinoma epithelial cell line) and L929 cells (as a standard cell line originated from mouse fibroblast cells).Methods: After culturing the cells in Roswell Park Memorial Institute (RPMI) medium, the cells were incubated with different doses of ALPINIA GALANGAL (0 (control), 125, 250, 500, 750 and 1000 mg/ml) in 24, 48 and 72 hour periods and then, cells viability were assessed using MTT based cell proliferation assay.Results: After 24 hours, the percentage of living AGS cells compared to the control group showed no significant decrease at the concentrations of 125 and 250mg/ml. But in the rest concentrations were significant (p<0.05). Only, the percentage of surviving L929 cells at concentration of 125mg/ml of the extract was not significant, but these percentages in the other concentrations were significant. After 48 and 72h incubation, in the last three extract concentrations, the percentage of living AGS and L929 cells significantly decreased compared to control cells (p<0.05).Conclusion: We have demonstrated, using cell culture model, anti-proliferative effect of aqueous extract of ALPINIA GALANGAL on human gastric tumor (AGS) and L929 cell lines. This effect was prominent in high concentrations.

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    APA: Copy

    HADJZADEH, MOSA AL REZA, GHANBARI, HABIB, KESHAVARZI, ZAKIEH, & TAVAKOL AFSHARI, JALIL. (2014). THE EFFECTS OF AQUEOUS EXTRACT OF ALPINIA GALANGAL ON GASTRIC CANCER CELLS (AGS) AND L929 CELLS IN VITRO. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), 7(3), 142-146. SID. https://sid.ir/paper/312628/en

    Vancouver: Copy

    HADJZADEH MOSA AL REZA, GHANBARI HABIB, KESHAVARZI ZAKIEH, TAVAKOL AFSHARI JALIL. THE EFFECTS OF AQUEOUS EXTRACT OF ALPINIA GALANGAL ON GASTRIC CANCER CELLS (AGS) AND L929 CELLS IN VITRO. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION)[Internet]. 2014;7(3):142-146. Available from: https://sid.ir/paper/312628/en

    IEEE: Copy

    MOSA AL REZA HADJZADEH, HABIB GHANBARI, ZAKIEH KESHAVARZI, and JALIL TAVAKOL AFSHARI, “THE EFFECTS OF AQUEOUS EXTRACT OF ALPINIA GALANGAL ON GASTRIC CANCER CELLS (AGS) AND L929 CELLS IN VITRO,” INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), vol. 7, no. 3, pp. 142–146, 2014, [Online]. Available: https://sid.ir/paper/312628/en

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