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Information Journal Paper

Title

ANTIGENIC CROSS-REACTIVITY ANTI-BIRTOXIN ANTIBODY AGAINST ANDROCTONUS CRASSICAUDA VENOM

Pages

  176-183

Abstract

 Background: Antivenom is still widely used in the treatment of envenomation as there are no vaccines or other effective agents available against animal VENOMs. Recently, neurotoxins named birtoxin family have been described from Parabuthus transvaalicus and ANDROCTONUS CRASSICAUDA. The aim of the present study was to test the antibirtoxin antibodies for their ability to neutralize the lethal effects of A. crassicauda scorpion VENOM.Methods: SDS-PAGE and Western blotting used the presence of components from A. crassicauda and P.transvaalicusscorpion VENOMs and to determine the degree of CROSS-REACTIVITY. The Minimum Lethal Dose (MLD) of VENOM was assessed by subcutaneously (sc) injections in mice.Results: The MLD of the A. crassicauda VENOM was 35 mg/ 20g mouse by sc injection route. Western blotting showed the presence of components from A. crassicauda and P. transvaalicus scorpion VENOMs strongly cross react with the A. crassicauda antivenom. However, Western blotting of the A. crassicauda scorpion VENOM using the Refik Saydam Public Health Agency (RSPHA) generated antibody showed that not all the VENOM components cross reacted with the ANTI-BIRTOXIN ANTIBODY. The antibodies only cross reacted with components falling under the 19 kDa protein size of A. crassicauda VENOM.Conclusion: The bioassays and Western blotting of A. crassicauda VENOM with the anti-birtoxin antibodies produced against a synthetic peptide showed that these antibodies cross reacted but did not neutralize the VENOM of A. crassicauda.

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    APA: Copy

    VAN ZOELEN, SUHANDAN ADIGUZEL, OZKAN, OZCAN, & INCEOGLU, BORA. (2015). ANTIGENIC CROSS-REACTIVITY ANTI-BIRTOXIN ANTIBODY AGAINST ANDROCTONUS CRASSICAUDA VENOM. JOURNAL OF ARTHROPOD-BORNE DISEASES, 9(2), 176-183. SID. https://sid.ir/paper/312858/en

    Vancouver: Copy

    VAN ZOELEN SUHANDAN ADIGUZEL, OZKAN OZCAN, INCEOGLU BORA. ANTIGENIC CROSS-REACTIVITY ANTI-BIRTOXIN ANTIBODY AGAINST ANDROCTONUS CRASSICAUDA VENOM. JOURNAL OF ARTHROPOD-BORNE DISEASES[Internet]. 2015;9(2):176-183. Available from: https://sid.ir/paper/312858/en

    IEEE: Copy

    SUHANDAN ADIGUZEL VAN ZOELEN, OZCAN OZKAN, and BORA INCEOGLU, “ANTIGENIC CROSS-REACTIVITY ANTI-BIRTOXIN ANTIBODY AGAINST ANDROCTONUS CRASSICAUDA VENOM,” JOURNAL OF ARTHROPOD-BORNE DISEASES, vol. 9, no. 2, pp. 176–183, 2015, [Online]. Available: https://sid.ir/paper/312858/en

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