مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

SPECIFIC ANTIVENOM ABILITY IN NEUTRALIZING HEPATIC AND RENAL CHANGES 24 HOURS AFTER LATRODECTUS DAHLI ENVENOMATION

Pages

  238-245

Abstract

 Background: Latrodectism, a syndrome caused by Latrodectus genus, is one of the clinical problems that occur predominantly in north east of Iran. Nowadays ANTIVENOM therapy has become the most useful treatment for animal bites; however there is still a controversy about route and time of ANTIVENOM administration in spider bite. The aim of the present study was to determine the efficacy of specific ANTIVENOM in neutralizing hepatic and renal symptoms 24 h after Latrodectus dahli envenomation.Methods: We selected a group of male New Zealand white rabbits, weighing 2±0.3 kg. The L. DAHLI VENOM (0.5 mg/kg) was injected subcutaneously. Specific ANTIVENOM (2.5 ml, I.V) was injected 24 h following VENOM injection. Blood sampling was performed before and 24 h after VENOM injection, as well within 24, 48 and 72 h after ANTIVENOM administration. Serum levels of (aspartate amino transferase (AST) alanine amino transferase (ALT), alkaline phosphatase (ALP), urea, bilirubin, creatinine and albumin were determined in all the sam.Results: Latrodectus dahli VENOM caused significant increase (P<0.05) in all foresaid serum parameters. ANTIVENOM reversed the AST, ALP, creatinine, urea and bilirubin to normal levels, but failed about ALT level, also nonsignificant decrease was observed in albumin levels.Conclusion: ANTIVENOM administration 24 h after VENOM injection can greatly reverse symptoms caused by VENOM. Future studies in human beings should be conducted to assess the protection against the specific-Latrodectus ANTIVENOM.

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    APA: Copy

    VALIKHANFARD ZANJANI, ELHAM, ZARE MIRAKABADI, ABBAS, ORYAN, SHAHRBANOO, GOODARZI, HAMID REZA, & RAJABI, MAHDISE. (2016). SPECIFIC ANTIVENOM ABILITY IN NEUTRALIZING HEPATIC AND RENAL CHANGES 24 HOURS AFTER LATRODECTUS DAHLI ENVENOMATION. JOURNAL OF ARTHROPOD-BORNE DISEASES, 10(2), 238-245. SID. https://sid.ir/paper/312912/en

    Vancouver: Copy

    VALIKHANFARD ZANJANI ELHAM, ZARE MIRAKABADI ABBAS, ORYAN SHAHRBANOO, GOODARZI HAMID REZA, RAJABI MAHDISE. SPECIFIC ANTIVENOM ABILITY IN NEUTRALIZING HEPATIC AND RENAL CHANGES 24 HOURS AFTER LATRODECTUS DAHLI ENVENOMATION. JOURNAL OF ARTHROPOD-BORNE DISEASES[Internet]. 2016;10(2):238-245. Available from: https://sid.ir/paper/312912/en

    IEEE: Copy

    ELHAM VALIKHANFARD ZANJANI, ABBAS ZARE MIRAKABADI, SHAHRBANOO ORYAN, HAMID REZA GOODARZI, and MAHDISE RAJABI, “SPECIFIC ANTIVENOM ABILITY IN NEUTRALIZING HEPATIC AND RENAL CHANGES 24 HOURS AFTER LATRODECTUS DAHLI ENVENOMATION,” JOURNAL OF ARTHROPOD-BORNE DISEASES, vol. 10, no. 2, pp. 238–245, 2016, [Online]. Available: https://sid.ir/paper/312912/en

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