DYSREGULATION OF THE WNT SIGNALING PATHWAY THROUGH METHYLATION OF WNT INHIBITORY FACTOR 1 AND DICKKOPF-1 GENES AMONG AML PATIENTS AT THE TIME OF DIAGNOSIS

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GHASEMI A.; GHOTASLOU A.; MOHAMMADI M.; GHAFFARI K.; ABBASIAN S.

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Journal: Iranian Journal of Blood and Cancer Year:2014 | Volume:7 | Issue:1 Page(s): 11-17

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Title

DYSREGULATION OF THE WNT SIGNALING PATHWAY THROUGH METHYLATION OF WNT INHIBITORY FACTOR 1 AND DICKKOPF-1 GENES AMONG AML PATIENTS AT THE TIME OF DIAGNOSIS

Author(s)

Keywords

AML

WNT INHIBITORY FACTOR 1

DICKKOPF

DNA METHYLATION

Abstract

Background: In acute myeloblastic leukemia, a large number of tumor suppressor genes are silenced through DNA METHYLATION such as CDKN2B & p73. WNT INHIBITORY FACTOR 1 (WIF1) and DICKKOPF-3 (DKK-1) are negative regulators of Wnt signaling pathway. In the present study, we evaluated the methylation status of WIF1 and DKK-1 genes in acute myeloblastic leukemia patients.Patients and Methods: Blood samples were taken from 120 AML patients and 25 healthy control subjects. DNA was isolated, treated with sodium bisulphite, and examined using methylation-specific polymerase chain reaction (MSP) with primers specific for methylated and unmethylated sequences of the WIF1 and DKK-1 genes.Results: The frequency of aberrant hyper methylation of WIF1 and DKK-1 genes in acute myeloblastic leukemia patients were determined to be 35% (42/120) and 28.3% (34/120), respectively. In addition, for all subjects in control group, methylation of WIF1 and DKK-1 genes were negative. Patients with M0 subtype of FAB-AML had the highest incidence of hyper methylation of WIF1 (P=0.003) and DKK-1 (P=0.005) genes.Conclusion: The present study showed that, like many solid tumors, WIF1 and DKK-1 genes methylation also occurs in acute myeloblastic leukemia. The study of other antagonists of Wnt signaling pathways are recommended.

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APA: Copy

GHASEMI, A., GHOTASLOU, A., MOHAMMADI, M., GHAFFARI, K., & ABBASIAN, S.. (2014). DYSREGULATION OF THE WNT SIGNALING PATHWAY THROUGH METHYLATION OF WNT INHIBITORY FACTOR 1 AND DICKKOPF-1 GENES AMONG AML PATIENTS AT THE TIME OF DIAGNOSIS. IRANIAN JOURNAL OF BLOOD AND CANCER (IJBC), 7(1), 11-17. SID. https://sid.ir/paper/313230/en

Vancouver: Copy

GHASEMI A., GHOTASLOU A., MOHAMMADI M., GHAFFARI K., ABBASIAN S.. DYSREGULATION OF THE WNT SIGNALING PATHWAY THROUGH METHYLATION OF WNT INHIBITORY FACTOR 1 AND DICKKOPF-1 GENES AMONG AML PATIENTS AT THE TIME OF DIAGNOSIS. IRANIAN JOURNAL OF BLOOD AND CANCER (IJBC)[Internet]. 2014;7(1):11-17. Available from: https://sid.ir/paper/313230/en

IEEE: Copy

A. GHASEMI, A. GHOTASLOU, M. MOHAMMADI, K. GHAFFARI, and S. ABBASIAN, “DYSREGULATION OF THE WNT SIGNALING PATHWAY THROUGH METHYLATION OF WNT INHIBITORY FACTOR 1 AND DICKKOPF-1 GENES AMONG AML PATIENTS AT THE TIME OF DIAGNOSIS,” IRANIAN JOURNAL OF BLOOD AND CANCER (IJBC), vol. 7, no. 1, pp. 11–17, 2014, [Online]. Available: https://sid.ir/paper/313230/en

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