QUANTITATIVE IMMUNOPHEMOTYPING OF PLATELET SURFACE GLYCOPROTEINS AMONG IRANIAN PATIENTS WITH BERNARD-SOULIER SYNDROME

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HADJATI S.; FARSINEJAD A.; FARANOUSH M.; GHAREHBAGHIAN A.; AMIRIZADEH N.; TOOGEH GH.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Blood and Cancer Year:2014 | Volume:7 | Issue:1 Page(s): 3-9

Download Full-Text

View:

211

Download:

104

Cites:

Information Journal Paper

Title

QUANTITATIVE IMMUNOPHEMOTYPING OF PLATELET SURFACE GLYCOPROTEINS AMONG IRANIAN PATIENTS WITH BERNARD-SOULIER SYNDROME

Author(s)

Keywords

BERNARD SOULIER SYNDROME

GPIB-IX-V

FLOW CYTOMETRY

BLEEDING

Abstract

Background: Bernard-Soulier syndrome is a rare inherited BLEEDING disease caused by quantitative or qualitative defect of GPIb/IX/V, a platelet complex that binds the Von Willebrand factor. The expression of GPIB-IX-V complex can be evaluated by FLOW CYTOMETRY and confirmed by the absence of ristocetin-induced platelet aggregation in platelet-rich plasma. The main aim of the present study was to classify Iranian Bernard-Soulier syndrome patients by a flow cytometric method, and to evaluate the correlation between platelet immunophenotype and clinical findings among patients.Patients and Methods: The surface expression level of GPIB-IX-V on platelets was assessed in fifteen Bernard-Soulier syndrome patients, using a panel of antibodies using a quantitative FLOW CYTOMETRY method. The results of the physical examination, family history and clinical presentation were also recorded by a physician.Result: The present study showed that all the patients suffer from a severe form of GPIB-IX-V complex deficiency.The study also found no correlation between the platelet surface glycoprotein expression and severity of BLEEDING among patients.Conclusion: Severe quantitative defect is the most common subtype among Iranian patients with Bernard-Soulier syndrome. Platelet Immunophenotyping alone does not determine the severity of hemorrhage in patients with Bernard-Soulier syndrome.

Cites

No record.

References

No record.

Cite

APA: Copy

HADJATI, S., FARSINEJAD, A., FARANOUSH, M., GHAREHBAGHIAN, A., AMIRIZADEH, N., & TOOGEH, GH.. (2014). QUANTITATIVE IMMUNOPHEMOTYPING OF PLATELET SURFACE GLYCOPROTEINS AMONG IRANIAN PATIENTS WITH BERNARD-SOULIER SYNDROME. IRANIAN JOURNAL OF BLOOD AND CANCER (IJBC), 7(1), 3-9. SID. https://sid.ir/paper/313231/en

Vancouver: Copy

HADJATI S., FARSINEJAD A., FARANOUSH M., GHAREHBAGHIAN A., AMIRIZADEH N., TOOGEH GH.. QUANTITATIVE IMMUNOPHEMOTYPING OF PLATELET SURFACE GLYCOPROTEINS AMONG IRANIAN PATIENTS WITH BERNARD-SOULIER SYNDROME. IRANIAN JOURNAL OF BLOOD AND CANCER (IJBC)[Internet]. 2014;7(1):3-9. Available from: https://sid.ir/paper/313231/en

IEEE: Copy

S. HADJATI, A. FARSINEJAD, M. FARANOUSH, A. GHAREHBAGHIAN, N. AMIRIZADEH, and GH. TOOGEH, “QUANTITATIVE IMMUNOPHEMOTYPING OF PLATELET SURFACE GLYCOPROTEINS AMONG IRANIAN PATIENTS WITH BERNARD-SOULIER SYNDROME,” IRANIAN JOURNAL OF BLOOD AND CANCER (IJBC), vol. 7, no. 1, pp. 3–9, 2014, [Online]. Available: https://sid.ir/paper/313231/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops