THE ANTICANCER ACTIVITY COMPARED BETWEEN TRIPTORELIN AND A NEW GONADOTROPIN RELEASING HORMONE ANALOGUE

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MIRZAEI SALEHABADI M.; ALIZADEH A.A.; SHAMSIPOUR F.; NADERIMANESH H.

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Journal Paper

Paper Information

Journal: Avicenna Journal of Medical Biotechnology Year:2009 | Volume:1 | Issue:2 Page(s): 105-110

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Title

THE ANTICANCER ACTIVITY COMPARED BETWEEN TRIPTORELIN AND A NEW GONADOTROPIN RELEASING HORMONE ANALOGUE

Author(s)

MIRZAEI SALEHABADI M. | ALIZADEH A.A. | SHAMSIPOUR F. | NADERIMANESH H. | Issue Writer Certificate

Keywords

ANTICANCER ACTIVITY

BREAST CANCER

LHRH ANALOGUE

OVARIAN CANCER

PEPTIDOMIMETICS

TRIPTORELIN

Abstract

Gonadotropin releasing hormone (GnRH) plays a key role in reproduction. This decapeptide is synthesized and released by hypothalamus and induces the pituitary gonadotrop cells to release pituitary gonadotropin hormones. In some extrapituitary compartments GnRH and its receptor act as part of the autocrine regulatory system of cell proliferation. The ANTICANCER ACTIVITY of GnRH and its analogues has been observed by many researchers. In this study the ANTICANCER ACTIVITY of a new analogue of GnRH and TRIPTORELIN was investigated by cell proliferation assay. Results indicate that proliferation of human breast and OVARIAN CANCER cell lines are dose-dependently inhibited. The inhibitory efficiency of the new analogue is proved to be higher than the original TRIPTORELIN. In addition to its antimitogenic activity, evidence was found for the involvement of the apoptotic mechanism in the action of the new analogue and TRIPTORELIN. In conclusion, the new analogue can be considered as a good pharmaceutical candidate.

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APA: Copy

MIRZAEI SALEHABADI, M., ALIZADEH, A.A., SHAMSIPOUR, F., & NADERIMANESH, H.. (2009). THE ANTICANCER ACTIVITY COMPARED BETWEEN TRIPTORELIN AND A NEW GONADOTROPIN RELEASING HORMONE ANALOGUE. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 1(2), 105-110. SID. https://sid.ir/paper/313706/en

Vancouver: Copy

MIRZAEI SALEHABADI M., ALIZADEH A.A., SHAMSIPOUR F., NADERIMANESH H.. THE ANTICANCER ACTIVITY COMPARED BETWEEN TRIPTORELIN AND A NEW GONADOTROPIN RELEASING HORMONE ANALOGUE. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2009;1(2):105-110. Available from: https://sid.ir/paper/313706/en

IEEE: Copy

M. MIRZAEI SALEHABADI, A.A. ALIZADEH, F. SHAMSIPOUR, and H. NADERIMANESH, “THE ANTICANCER ACTIVITY COMPARED BETWEEN TRIPTORELIN AND A NEW GONADOTROPIN RELEASING HORMONE ANALOGUE,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 1, no. 2, pp. 105–110, 2009, [Online]. Available: https://sid.ir/paper/313706/en

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