مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

COMPARATIVE PROTEOMICS STUDY OF STREPTOZOTOCIN-INDUCED DIABETIC NEPHROPATHY IN RATS KIDNEYS TRANSFECTED WITH ADENOVIRUS-MEDIATED FIBROMODULIN GENE

Pages

  104-112

Abstract

 Background: Transforming Growth Factor-beta (TGF-b) activation appears to be crucial for tissue injury in DIABETIC NEPHROPATHY (DN). FIBROMODULIN, the small leucine-rich proteoglycan, has been proposed to be the potent TGF-b modulator. In this study, the therapeutic effects of FIBROMODULIN in the kidneys of streptozotocin (STZ)-induced diabetic rats were investigated. Methods: Diabetic rats received intraperitoneal (IP) injections of recombinant adenovirus expression vectors (RAd5) containing FIBROMODULIN (RAd-FMOD) and were killed after 10 weeks. Proteins were isolated from the rat kidney and separated using two-dimensional gel electrophoresis. The differentially expressed proteins were analyzed using Matrix-assisted laser desorption/ ioni-zation time-of-flight mass spectrometry (MALDI-TOF-MS). Results: Ten spots were identified using MALDI-TOF-MS. The identified proteins were primarily responsible for cell metabolism, cytoskeleton formation, and oxidative stress. RAd-FMOD treatment markedly attenuated the albuminuria in diabetic rats.Conclusion: Taken together, these results provide a valuable clue in exploring the mechanism underlying the therapeutic effects of FIBROMODULIN in DIABETIC NEPHROPATHY suggesting that it can be a potential agent in the treatment of this disease.

Cites

References

Cite

APA: Copy

MALEKI, AKRAM, RAMAZANI, ALI, FOROUTAN, MARYAM, BIGLARI, ALIREZA, RANJZAD, PARISA, & MELLATI, ALI AWSAT. (2014). COMPARATIVE PROTEOMICS STUDY OF STREPTOZOTOCIN-INDUCED DIABETIC NEPHROPATHY IN RATS KIDNEYS TRANSFECTED WITH ADENOVIRUS-MEDIATED FIBROMODULIN GENE. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 6(2), 104-112. SID. https://sid.ir/paper/313834/en

Vancouver: Copy

MALEKI AKRAM, RAMAZANI ALI, FOROUTAN MARYAM, BIGLARI ALIREZA, RANJZAD PARISA, MELLATI ALI AWSAT. COMPARATIVE PROTEOMICS STUDY OF STREPTOZOTOCIN-INDUCED DIABETIC NEPHROPATHY IN RATS KIDNEYS TRANSFECTED WITH ADENOVIRUS-MEDIATED FIBROMODULIN GENE. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2014;6(2):104-112. Available from: https://sid.ir/paper/313834/en

IEEE: Copy

AKRAM MALEKI, ALI RAMAZANI, MARYAM FOROUTAN, ALIREZA BIGLARI, PARISA RANJZAD, and ALI AWSAT MELLATI, “COMPARATIVE PROTEOMICS STUDY OF STREPTOZOTOCIN-INDUCED DIABETIC NEPHROPATHY IN RATS KIDNEYS TRANSFECTED WITH ADENOVIRUS-MEDIATED FIBROMODULIN GENE,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 6, no. 2, pp. 104–112, 2014, [Online]. Available: https://sid.ir/paper/313834/en

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