AUTISTIC DISORDERS AND MEDICAL BIOTECHNOLOGY (EDITORIAL)

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AKHONDZADEH SHAHIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Avicenna Journal of Medical Biotechnology Year:2015 | Volume:7 | Issue:1 Page(s): 0-0

Download Full-Text

View:

391

Download:

138

Cites:

Information Journal Paper

Title

AUTISTIC DISORDERS AND MEDICAL BIOTECHNOLOGY (EDITORIAL)

Author(s)

AKHONDZADEH SHAHIN | Issue Writer Certificate

Keywords

AUTISTIC DISORDER

BIOTECHNOLOGY

GENETIC DISEASES

Abstract

AUTISTIC DISORDERs (ADs) are neuro-developmental disorders in the category of pervasive developmental disorders chiefly described by three main deficits: 1) deviant communication, 2) impaired reciprocal social interaction, and 3) limited, repetitive and stereotypic patterns of behaviors or interests 1. The world-wide prevalence of ADs is estimated to be 62/10, 000 1. Although various treatment regimens have been proposed for improving overall function of autistic patients, a definite efficient treatment which can target both core and associated symptoms in ADs has not been established so far. For example, current approved drugs by the Food and Drug Administration (FDA) such as risperidone and aripiprazole have not been proven to pose significant effect on the core features of this disorder 2-4.While the absolute pathophysiologic mechanism of ADs is still debated, several genetic, environmental and neurobiological factors such as immune dysfunction, oxidative stress and imbalance of the inhibitory-excitatory systems are implicated in the pathogenesis of these disorders 5-7. Neurobiological models have become research areas of interest for development of novel therapeutic agents in this regard 1. Increased neuronal excitation in various central pathways has been proposed as one of the main neurobiological dysregulations in autistic patients 1. Indeed, BIOTECHNOLOGY and in particular gene therapies plays an important role in the future of research in autism 1.Neurexin 1: Part of family of genes that play a role with the neurotransmitter glutamate which is linked to autism.Gene chip technology was used to scan for genetic similarities in people with autism. DNA was scanned to search for copy number variations (CNVs), or insertions and deletions of genetic material linked to autism 1.Adult Form of Fragile X Syndrome: Expression of toxic RNA leads to Fragile X Tremor Ataxia Syndrome is modifiable by gene therapy 1.Fragile X Syndrome: Caused by loss of a gene called FMPR which acts as a break on a protein synthesis in specific area of the brain. This allows another protein, mGluR5 Metabotropic Glutamate Receptor, to function unchecked resulting in over activity in the brain. Reducing mGluR5 reduces symptoms associated with fragile x syndrome 1.MECP2 Activation of the gene reversed Rett syndrome. The MECP2 gene mutation is present in 95 percent of individuals with the disease 1.

Cites

No record.

References

Cite

APA: Copy

AKHONDZADEH, SHAHIN. (2015). AUTISTIC DISORDERS AND MEDICAL BIOTECHNOLOGY (EDITORIAL). AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 7(1), 0-0. SID. https://sid.ir/paper/313856/en

Vancouver: Copy

AKHONDZADEH SHAHIN. AUTISTIC DISORDERS AND MEDICAL BIOTECHNOLOGY (EDITORIAL). AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2015;7(1):0-0. Available from: https://sid.ir/paper/313856/en

IEEE: Copy

SHAHIN AKHONDZADEH, “AUTISTIC DISORDERS AND MEDICAL BIOTECHNOLOGY (EDITORIAL),” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 7, no. 1, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/313856/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops