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Information Journal Paper

Title

MAJOR COMPONENTS OF METABOLIC PARAMETERS AND NUTRITIONAL INTAKES IN DIFFERENT GENOTYPES OF ADIPONECTIN +276 G>T GENE POLYMORPHISM IN NON-DIABETES AND NON-ALCOHOLIC IRANIAN FATTY LIVER PATIENTS

Pages

  155-161

Keywords

NONALCOHOLIC FATTY LIVER DISEASE (NAFLD) 

Abstract

 Background: Genetic and environmental factors are both involved in the etiology of Non-Alcoholic Fatty Liver Disease (NAFLD). Among the genetic factors, certain POLYMORPHISMs of ADIPONECTIN gene are associated with NAFLD. In the current study, we investigated the association between metabolic parameters with different genotypes of ADIPONECTIN +276 G>T POLYMORPHISM among the Iranian NAFLD patients, and the effect of nutritional intake with development of NAFLD.Methods: In this study, 75 patients with NAFLD and 76 healthy individuals were enrolled. Dietary intakes were assessed using a semi- quantitative Food-Frequency Questionnaire (FFQ). Body Mass Index (BMI) and Waist to Hip Ratio (WHR) were calculated. Biochemical assays including FSG (Fasting Serum Glucose), liver enzymes, lipid profiles, Malondialdehyde, insulin resistance and Total Antioxidant Capacity (TAC) were measured after 12 hr fasting. Gene POLYMORPHISM study was done by using of sequencing method.Results: Although, T allele frequency was more prevalent in patients with NAFLD than control, ADIPONECTIN +276 G>T POLYMORPHISM was not associated with risk of NAFLD. Among the metabolic parameters, TAC in TT genotype was significantly lower 1.44(0.69 to 2.81) p>0.05, AST in GT, GG genotypes, and ALT in all three genotypes were higher in NAFLD patients in compared to healthy subjects (p<0.05). Patients with GT genotype have significantly lower fat consumption and vitamin E intake as compared to control group with the same genotype (p<0.05).Conclusion: In this study, we showed the association of different genotypes of +276 G>T POLYMORPHISM in ADIPONECTIN gene with some metabolic parameters.

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    APA: Copy

    MOHSENI, FATEMEH, MOGHBELINEJAD, SAHAR, & NAJAFIPOUR, REZA. (2017). MAJOR COMPONENTS OF METABOLIC PARAMETERS AND NUTRITIONAL INTAKES IN DIFFERENT GENOTYPES OF ADIPONECTIN +276 G>T GENE POLYMORPHISM IN NON-DIABETES AND NON-ALCOHOLIC IRANIAN FATTY LIVER PATIENTS. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 9(3), 155-161. SID. https://sid.ir/paper/313917/en

    Vancouver: Copy

    MOHSENI FATEMEH, MOGHBELINEJAD SAHAR, NAJAFIPOUR REZA. MAJOR COMPONENTS OF METABOLIC PARAMETERS AND NUTRITIONAL INTAKES IN DIFFERENT GENOTYPES OF ADIPONECTIN +276 G>T GENE POLYMORPHISM IN NON-DIABETES AND NON-ALCOHOLIC IRANIAN FATTY LIVER PATIENTS. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2017;9(3):155-161. Available from: https://sid.ir/paper/313917/en

    IEEE: Copy

    FATEMEH MOHSENI, SAHAR MOGHBELINEJAD, and REZA NAJAFIPOUR, “MAJOR COMPONENTS OF METABOLIC PARAMETERS AND NUTRITIONAL INTAKES IN DIFFERENT GENOTYPES OF ADIPONECTIN +276 G>T GENE POLYMORPHISM IN NON-DIABETES AND NON-ALCOHOLIC IRANIAN FATTY LIVER PATIENTS,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 9, no. 3, pp. 155–161, 2017, [Online]. Available: https://sid.ir/paper/313917/en

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