مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

ASSOCIATION OF ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1)-565 C/T GENE POLYMORPHISM WITH HYPOALPHALIPOPROTEINEMIA AND SERUM LIPIDS, IL-6 AND CRP LEVELS

Pages

  38-43

Abstract

 Background: ATP-binding cassette transporter A1 (ABCA1) is a membrane integral protein which plays a vital role in High Density Lipoprotein (HDL) metabolism and exerts a protective effect against HYPOALPHALIPOPROTEINEMIA (HA) by mediation of rate-limiting step in HDL biogenesis. In addition, this protein possesses anti-inflammatory effects by inhibiting the production of some inflammatory cytokines in macrophages.This study investigated the association ofABCA1-565 C/T gene polymorphism with HA and serum LIPIDS, IL-6 and CRP levels.Methods: A population which consisted of 101 HA and 95 normal subjects were genotyped forABCA1-565C/T polymorphism by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). The serum concentrations of LIPIDS, IL-6 and high sensitive-CRP (hs-CRP) were measured by the relevant methods.Results: The frequency of T allele was significantly higher in the HA group than the controls (31.7vs.19.5%, p=0.002). Thus, carriers of the T allele (CT and TT genotypes) had a higher risk for HA (p=0.016, OR=2.04, 95% CI=1.14-3.63). T allele carriers demonstrated decreased HDL-C and increased triglyceride, IL-6 and CRP levels than those with the CC genotype.Conclusion: This study suggests that the-565 C/T POLYMORPHISM of ABCA1 gene is associated with an increased risk of HA, decreased HDL-C and increased TG, IL-6 and CRP.

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    APA: Copy

    BABASHAMSI, MOHAMMAD MAHDI, HALALKHOR, SOHRAB, MORADI FIROUZJAH, HAMID, PARSIAN, HADI, JALALI, SEYED FARZAD, & BABASHAMSI, MOHAMMAD. (2017). ASSOCIATION OF ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1)-565 C/T GENE POLYMORPHISM WITH HYPOALPHALIPOPROTEINEMIA AND SERUM LIPIDS, IL-6 AND CRP LEVELS. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 9(1), 38-43. SID. https://sid.ir/paper/313930/en

    Vancouver: Copy

    BABASHAMSI MOHAMMAD MAHDI, HALALKHOR SOHRAB, MORADI FIROUZJAH HAMID, PARSIAN HADI, JALALI SEYED FARZAD, BABASHAMSI MOHAMMAD. ASSOCIATION OF ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1)-565 C/T GENE POLYMORPHISM WITH HYPOALPHALIPOPROTEINEMIA AND SERUM LIPIDS, IL-6 AND CRP LEVELS. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2017;9(1):38-43. Available from: https://sid.ir/paper/313930/en

    IEEE: Copy

    MOHAMMAD MAHDI BABASHAMSI, SOHRAB HALALKHOR, HAMID MORADI FIROUZJAH, HADI PARSIAN, SEYED FARZAD JALALI, and MOHAMMAD BABASHAMSI, “ASSOCIATION OF ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1)-565 C/T GENE POLYMORPHISM WITH HYPOALPHALIPOPROTEINEMIA AND SERUM LIPIDS, IL-6 AND CRP LEVELS,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 9, no. 1, pp. 38–43, 2017, [Online]. Available: https://sid.ir/paper/313930/en

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