THE EFFECTS OF BERBERINE AND PALMATINE ON EFFLUX PUMPS INHIBITION WITH DIFFERENT GENE PATTERNS IN PSEUDOMONAS AERUGINOSA ISOLATED FROM BURN INFECTIONS

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AGHAYAN SEYED SAJJAD; KALALIAN MOGADAM HAMIDREZA; Fazli Mozhgan; DARBAN SAROKHALIL DAVOOD; Khoramrooz seyed Sajad; JABAL AMELI FERESHTEH; YASLIANIFARD SOMAYEH; MIRZAII MEHDI

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Journal: Avicenna Journal of Medical Biotechnology Year:2017 | Volume:9 | Issue:1 Page(s): 2-7

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Title

THE EFFECTS OF BERBERINE AND PALMATINE ON EFFLUX PUMPS INHIBITION WITH DIFFERENT GENE PATTERNS IN PSEUDOMONAS AERUGINOSA ISOLATED FROM BURN INFECTIONS

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Keywords

BERBERINE

PALMATINE

PSEUDOMONAS AERUGINOSA

Abstract

Background: Related Multidrug Resistance (MDR) to efflux pumps is a significant problem in treating infections caused byPseudomonas aeruginosa (P. aeruginosa).Plant compounds have been identified as Pump Inhibitors (EPIs). In the current study, the potential effect of BERBERINE and PALMATINE as EPIs were investigated on efflux pump inhibition through focusing on different gene patterns inP. aeruginosa isolated from burn infections.Methods: All isolates were collected and identified using the standard biochemical tests. Antimicrobial sensitivity was performed based on disk agar diffusion method for 12 antibiotics. MIC-MBC tests were also performed based on the broth microdilution method to detect synergistic relationship between ciprofloxacin, BERBERINE and PALMATINE.Detection ofmexA, mexB, mexC, mexD, mexE, mexF and mexX was conducted by PCR assay. Fisher's Exact test and Logistic Regression were used as statistical tools.Results: A total of 60 P. aeruginosa isolates were collected. The highest and lowest levels of resistance were found to be respectively against clindamycin and tigecycline.Comparing the MIC with MBC distribution, it was found that BERBERINE and PALMATINE lower the MIC-MBC level of ciprofloxacin. The PCR results indicated that the highest frequency is about MexAB-OprM operon. The statistical analysis among different gene patterns of efflux pumps showed that there were no significant relationships between the effectiveness of BERBERINE and PALMATINE (p>0.05).Conclusion: It can be speculated that BERBERINE and PALMATINE both act as EPIs and can be used as auxiliary treatments with the purpose of increasing the effect of available antibiotics as well as decreasing the emergence of MDR bacteria. The efficiency of these combinations should be studied further underin vivo conditions to have a more comprehensive conclusion regarding this issue.

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APA: Copy

AGHAYAN, SEYED SAJJAD, KALALIAN MOGADAM, HAMIDREZA, Fazli, Mozhgan, DARBAN SAROKHALIL, DAVOOD, Khoramrooz, seyed Sajad, JABAL AMELI, FERESHTEH, YASLIANIFARD, SOMAYEH, & MIRZAII, MEHDI. (2017). THE EFFECTS OF BERBERINE AND PALMATINE ON EFFLUX PUMPS INHIBITION WITH DIFFERENT GENE PATTERNS IN PSEUDOMONAS AERUGINOSA ISOLATED FROM BURN INFECTIONS. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 9(1), 2-7. SID. https://sid.ir/paper/313933/en

Vancouver: Copy

AGHAYAN SEYED SAJJAD, KALALIAN MOGADAM HAMIDREZA, Fazli Mozhgan, DARBAN SAROKHALIL DAVOOD, Khoramrooz seyed Sajad, JABAL AMELI FERESHTEH, YASLIANIFARD SOMAYEH, MIRZAII MEHDI. THE EFFECTS OF BERBERINE AND PALMATINE ON EFFLUX PUMPS INHIBITION WITH DIFFERENT GENE PATTERNS IN PSEUDOMONAS AERUGINOSA ISOLATED FROM BURN INFECTIONS. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2017;9(1):2-7. Available from: https://sid.ir/paper/313933/en

IEEE: Copy

SEYED SAJJAD AGHAYAN, HAMIDREZA KALALIAN MOGADAM, Mozhgan Fazli, DAVOOD DARBAN SAROKHALIL, seyed Sajad Khoramrooz, FERESHTEH JABAL AMELI, SOMAYEH YASLIANIFARD, and MEHDI MIRZAII, “THE EFFECTS OF BERBERINE AND PALMATINE ON EFFLUX PUMPS INHIBITION WITH DIFFERENT GENE PATTERNS IN PSEUDOMONAS AERUGINOSA ISOLATED FROM BURN INFECTIONS,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 9, no. 1, pp. 2–7, 2017, [Online]. Available: https://sid.ir/paper/313933/en

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