CLINICALLY SIGNIFICANT DYSREGULATION OF HSA-MIR-30D-5P AND HSA-LET-7B EXPRESSION IN PATIENTS WITH SURGICALLY RESECTED NON-SMALL CELL LUNG CANCER

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HOSSEINI SEYED MOSTAFA; MOHAMMAD SOLTANI BAHRAM; TAVALLAEI MAHMOOD; MOWLA SEYED JAVAD; TAFSIRI ELHAM; BAGHERI ABOUZAR; KHORRAM KHORSHID HAMID REZA

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Journal: Avicenna Journal of Medical Biotechnology Year:2018 | Volume:10 | Issue:2 Page(s): 98-104

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Title

CLINICALLY SIGNIFICANT DYSREGULATION OF HSA-MIR-30D-5P AND HSA-LET-7B EXPRESSION IN PATIENTS WITH SURGICALLY RESECTED NON-SMALL CELL LUNG CANCER

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Keywords

LUNG CANCER

MICRORNAS

TUMOR MARKERS

Abstract

Background: The cyclin E2 (CYCE2) is an important regulator in the progression and development of NSCLC, and its ectopic expression promoted the proliferation, invasion, and migration in several tumors, including Non-Small Cell LUNG CANCER (NSCLC). However, the upregulation of CYCE2 in NSCLC cells suggested that it has a key role in tumorigenicity. In addition, the RAS family proteins as oncoproteins were activated in many major tumor types and its suitability as the therapeutic target in NSCLC was proposed. Considering the crucial role of MICRORNAS, it was hypothesized that altered expression ofhsa-miR-30d-5p and hsa-let-7b might provide a reliable diagnostic tumor marker for diagnosis of NSCLC.Method: Real-time RT-PCR approach could evaluate the expression alteration of hsa-miR-30d-5pand hsa-let-7b and it was related to the surgically resected tissue of 24 LUNG CANCER patients and 10 non-cancerous patients. The miRNAs expression was associated with clinicopathological features of the patients.Results: Hsa-miR-30d showed a significant downregulation (p=0.0382) in resected tissue of NSCLC patients compared with control group. Its expression level could differentiate different stages of malignancies from each other. The ROC curve analysis gave it an AUC=0.73 (p=0.037) which was a good score as a reliable biomarker. In contrast, hsa-let-7b was significantly overexpressed in tumor samples (p=0.03). Interestingly, our findings revealed a significant association ofhsa-let-7b in adenocarcinoma tumors, compared to Squamous Cell Carcinomas (SCC) (p<0.05). Also, analysis of ROC curve ofhsa-let-7b (AUC=0.74, p-value=0.042) suggests that it could be as a suitable biomarker for NSCLC.Conclusion: Together, these results suggest a possible tumor suppressor role for hsamiR-30din lung tumor progression and initiation. Moreover, upregulation of hsa-let- 7bwas associated with the tumor type.

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APA: Copy

HOSSEINI, SEYED MOSTAFA, MOHAMMAD SOLTANI, BAHRAM, TAVALLAEI, MAHMOOD, MOWLA, SEYED JAVAD, TAFSIRI, ELHAM, BAGHERI, ABOUZAR, & KHORRAM KHORSHID, HAMID REZA. (2018). CLINICALLY SIGNIFICANT DYSREGULATION OF HSA-MIR-30D-5P AND HSA-LET-7B EXPRESSION IN PATIENTS WITH SURGICALLY RESECTED NON-SMALL CELL LUNG CANCER. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 10(2), 98-104. SID. https://sid.ir/paper/313970/en

Vancouver: Copy

HOSSEINI SEYED MOSTAFA, MOHAMMAD SOLTANI BAHRAM, TAVALLAEI MAHMOOD, MOWLA SEYED JAVAD, TAFSIRI ELHAM, BAGHERI ABOUZAR, KHORRAM KHORSHID HAMID REZA. CLINICALLY SIGNIFICANT DYSREGULATION OF HSA-MIR-30D-5P AND HSA-LET-7B EXPRESSION IN PATIENTS WITH SURGICALLY RESECTED NON-SMALL CELL LUNG CANCER. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2018;10(2):98-104. Available from: https://sid.ir/paper/313970/en

IEEE: Copy

SEYED MOSTAFA HOSSEINI, BAHRAM MOHAMMAD SOLTANI, MAHMOOD TAVALLAEI, SEYED JAVAD MOWLA, ELHAM TAFSIRI, ABOUZAR BAGHERI, and HAMID REZA KHORRAM KHORSHID, “CLINICALLY SIGNIFICANT DYSREGULATION OF HSA-MIR-30D-5P AND HSA-LET-7B EXPRESSION IN PATIENTS WITH SURGICALLY RESECTED NON-SMALL CELL LUNG CANCER,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 10, no. 2, pp. 98–104, 2018, [Online]. Available: https://sid.ir/paper/313970/en

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