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Information Journal Paper

Title

ALTERED MIR-223 EXPRESSION IN SPUTUM FOR DIAGNOSIS OF NON-SMALL CELL LUNG CANCER

Pages

  189-195

Abstract

 Background: Diagnosis of Non-small Cell Lung Cancer (NSCLC) at an early stage is a daunting challenge due to the deficiency of specific noninvasive markers. MICRORNAS (miRNAs) play important roles in the initiation and progression of NSCLC. Measuring miRNA expression levels could provide a potential approach for the diagnosis of NSCLC. Our goals were to examine miR-223, miR-212, miR-192, miR-3074, SNORD33 and SNORD37 expression levels in tissue and SPUTUM of NSCLC patients and cancer free subjects for molecular diagnosis of NSCLC.Methods: Relative expressions of miR-223, miR-212, miR-192, miR-3074, SNORD33 and SNORD37 were examined with quantitative real-time RT-PCR assay in tissue and SPUTUM obtained from 17 NSCLC patients and 17 controls.Results: miR-3074 was upregulated in tissue samples of NSCLC patients compared with control group. miR-223 was upregulated, miR-212 and SNORD37 were downergulated in SPUTUM samples of patients compared with controls. miR-223 quantification produced 82% sensitivity and 95% specificity with areas under the ROC curve at 0.90 in detection of NSCLC.Conclusion: miR-223 clearly discriminated cancer patients from cancer-free subjects and our results suggest that miR-223 could be a diagnostic useful biomarker. The measurement of altered miRNA expression in SPUTUM samples manifested the potential noninvasive approach for detection of lung cancer.

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    APA: Copy

    BAGHERI, ABOUZAR, KHORRAM KHORSHID, HAMID REZA, MOWLA, SEYED JAVAD, MOHEBBI, HASSAN ALI, MOHAMMADIAN, AZAM, YASERI, MEHDI, SOLAYMANI DODARAN, MASOUD, SHERAFATIAN, MASIH, & Tavallaie, Mahmood. (2017). ALTERED MIR-223 EXPRESSION IN SPUTUM FOR DIAGNOSIS OF NON-SMALL CELL LUNG CANCER. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 9(4), 189-195. SID. https://sid.ir/paper/313976/en

    Vancouver: Copy

    BAGHERI ABOUZAR, KHORRAM KHORSHID HAMID REZA, MOWLA SEYED JAVAD, MOHEBBI HASSAN ALI, MOHAMMADIAN AZAM, YASERI MEHDI, SOLAYMANI DODARAN MASOUD, SHERAFATIAN MASIH, Tavallaie Mahmood. ALTERED MIR-223 EXPRESSION IN SPUTUM FOR DIAGNOSIS OF NON-SMALL CELL LUNG CANCER. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2017;9(4):189-195. Available from: https://sid.ir/paper/313976/en

    IEEE: Copy

    ABOUZAR BAGHERI, HAMID REZA KHORRAM KHORSHID, SEYED JAVAD MOWLA, HASSAN ALI MOHEBBI, AZAM MOHAMMADIAN, MEHDI YASERI, MASOUD SOLAYMANI DODARAN, MASIH SHERAFATIAN, and Mahmood Tavallaie, “ALTERED MIR-223 EXPRESSION IN SPUTUM FOR DIAGNOSIS OF NON-SMALL CELL LUNG CANCER,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 9, no. 4, pp. 189–195, 2017, [Online]. Available: https://sid.ir/paper/313976/en

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