SHORT COMMUNICATION: ALTERNATIVE SPLICING GENERATES DIFFERENT 5' UTRS IN OCT4B VARIANTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

M.POURSANI ENSIEH; MEHRAVAR MAJID; SHAHRIARI ALI REZA; MOWLA SEYED JAVAD; MOHAMMAD SOLTANI BAHRAM

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Avicenna Journal of Medical Biotechnology Year:2017 | Volume:9 | Issue:4 Page(s): 201-204

Download Full-Text

View:

252

Download:

183

Cites:

Information Journal Paper

Title

SHORT COMMUNICATION: ALTERNATIVE SPLICING GENERATES DIFFERENT 5' UTRS IN OCT4B VARIANTS

Author(s)

Keywords

ALTERNATIVE SPLICING

GENES

5’UNTRANSLATED REGIONS

Abstract

Background: The human OCT4 gene, responsible for pluripotency and self-renewal of Embryonic Stem (ES) and Embryonic Carcinoma (EC) cells, can generate several transcripts (OCT4A, OCT4B-variant 2, OCT4B-variant 3, OCT4B-variant 5, OCT4B1, OCT4 B2 and OCT4B3) by ALTERNATIVE SPLICING and alternative promoters. OCT4A that is responsible for ES and EC cell stemness properties is transcribed from a promoter upstream of Exon1a in those cells. The OCT4B group variants (OCT4B-variant2, OCT4Bvariant3, OCT4B-variant5, OCT4B1, OCT4B2 and OCT4B3) are transcribed from a different promoter located in intron 1 and some of them respond to the cell stresses, but cannot sustain the ES/EC cell self-renewal. However, the exact function of OCT4B group variants is still unclear.Methods: In the present study, we employed RT-PCR and sequencing approaches to explore different forms of OCT4 transcripts.Results: Our data revealed that the OCT4B group variants (OCT4B-variant2, OCT4 B-variant3, OCT4B1, OCT4B2 and OCT4B3) have longer 5' UTR in the human bladder carcinoma cell line of 5637.Conclusion: These OCT4 variants undergo ALTERNATIVE SPLICING in their 5' UTR which might exert regulatory roles in transcription and translation mechanisms.

Cites

No record.

References

No record.

Cite

APA: Copy

M.POURSANI, ENSIEH, MEHRAVAR, MAJID, SHAHRIARI, ALI REZA, MOWLA, SEYED JAVAD, & MOHAMMAD SOLTANI, BAHRAM. (2017). SHORT COMMUNICATION: ALTERNATIVE SPLICING GENERATES DIFFERENT 5' UTRS IN OCT4B VARIANTS. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 9(4), 201-204. SID. https://sid.ir/paper/313977/en

Vancouver: Copy

M.POURSANI ENSIEH, MEHRAVAR MAJID, SHAHRIARI ALI REZA, MOWLA SEYED JAVAD, MOHAMMAD SOLTANI BAHRAM. SHORT COMMUNICATION: ALTERNATIVE SPLICING GENERATES DIFFERENT 5' UTRS IN OCT4B VARIANTS. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2017;9(4):201-204. Available from: https://sid.ir/paper/313977/en

IEEE: Copy

ENSIEH M.POURSANI, MAJID MEHRAVAR, ALI REZA SHAHRIARI, SEYED JAVAD MOWLA, and BAHRAM MOHAMMAD SOLTANI, “SHORT COMMUNICATION: ALTERNATIVE SPLICING GENERATES DIFFERENT 5' UTRS IN OCT4B VARIANTS,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 9, no. 4, pp. 201–204, 2017, [Online]. Available: https://sid.ir/paper/313977/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops