Investigation of the Association between 5-Hydroxytryptamine Transporter Gene-Linked Polymorphic Region with Type 2 Diabetes Mellitus, Obesity and Biochemical Profiles of Serum in Iranian Population

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Asadzadeh Azizeh; SEYEDHOSSEINI GHAHEH HOORIA; Sholehvar Fatemeh; Takhshid Mohammadali; NAGHIZADEH MOHAMMAD MEHDI

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Journal: Avicenna Journal of Medical Biotechnology Year:2019 | Volume:11 | Issue:3 Page(s): 239-244

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Title

Investigation of the Association between 5-Hydroxytryptamine Transporter Gene-Linked Polymorphic Region with Type 2 Diabetes Mellitus, Obesity and Biochemical Profiles of Serum in Iranian Population

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Keywords

5-HTT gene

5-HTTLPR polymorphism

Serotonin

Type 2 diabetes mellitus

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a serious problem in the world. 5-Hydroxytryptamine (5-HT, Serotonin) plays an important role in obesity, glucose con-trol and insulin resistance. The polymorphism of the Serotonin transporter gene linked promoter region (5-HTTLPR) might influence 5-HTT expression and Serotonin uptake. The polymorphism results in two alleles of L (Long) and S (Short). The aim of the pre-sent study was to evaluate the association between 5-HTTLPR genotypes in Type 2 diabetes mellitus (T2DM), obesity as well as serum biochemical profiles in Iranian population from 2012 until 2015. Methods: 180 patients with T2DM and 180 controls were selected and the frequency of S and L alleles was determined by PCR. Then, the relationship between genotypes, body mass index (BMI) and serum biochemical variables was investigated. Results: The frequency of S and L alleles in experimental and control groups was the same [for the L allele p=0. 754, OR (95%CI)=1. 103 (0. 597 to 2. 041) and for the S allele p=0. 906, OR (95%CI)=(0. 490 to 1. 676)]. However, the mean triglyceride, cholesterol, LDL-C, systolic and diastolic blood pressure levels in the diabetic subjects with LL gen-otype were significantly higher than LS and SS genotypes (p<0. 001) in this population. Conclusion: The L allele of 5-HTTLPR was related to the increased serum lipids and blood pressure in the diabetic patients. However, there was no relationship between the polymorphism of 5-HTTLPR L/S and T2DM in Iranian population.

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APA: Copy

Asadzadeh, Azizeh, SEYEDHOSSEINI GHAHEH, HOORIA, Sholehvar, Fatemeh, Takhshid, Mohammadali, & NAGHIZADEH, MOHAMMAD MEHDI. (2019). Investigation of the Association between 5-Hydroxytryptamine Transporter Gene-Linked Polymorphic Region with Type 2 Diabetes Mellitus, Obesity and Biochemical Profiles of Serum in Iranian Population. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 11(3), 239-244. SID. https://sid.ir/paper/314037/en

Vancouver: Copy

Asadzadeh Azizeh, SEYEDHOSSEINI GHAHEH HOORIA, Sholehvar Fatemeh, Takhshid Mohammadali, NAGHIZADEH MOHAMMAD MEHDI. Investigation of the Association between 5-Hydroxytryptamine Transporter Gene-Linked Polymorphic Region with Type 2 Diabetes Mellitus, Obesity and Biochemical Profiles of Serum in Iranian Population. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2019;11(3):239-244. Available from: https://sid.ir/paper/314037/en

IEEE: Copy

Azizeh Asadzadeh, HOORIA SEYEDHOSSEINI GHAHEH, Fatemeh Sholehvar, Mohammadali Takhshid, and MOHAMMAD MEHDI NAGHIZADEH, “Investigation of the Association between 5-Hydroxytryptamine Transporter Gene-Linked Polymorphic Region with Type 2 Diabetes Mellitus, Obesity and Biochemical Profiles of Serum in Iranian Population,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 11, no. 3, pp. 239–244, 2019, [Online]. Available: https://sid.ir/paper/314037/en

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