مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

265
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

171
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Anti-Influenza Virus Activity and Phenolic Content of Pomegranate (Punica granatum L. ) Peel Extract and Fractions

Author(s)

 Moradi Mohammad Taghi | KARIMI ALI | SHAHRANI MEHRDAD | HASHEMI LEILA | Ghaffari Goosheh Mohammad Saleh | Issue Writer Certificate 

Pages

  285-291

Abstract

 Background: Influenza virus, associated with high level of morbidity and mortality, has been recently considered a public health concern while the choices for the control and treatment of the disease are limited. The present study was conducted to evaluate activity of Pomegranate peel extract and its fractions against Influenza A virus in vitro. Methods: In this research, ethyl alcohol extract of Pomegranate peel was prepared and subjected to fractionation with different polarities. The potential in vitro anti-influenza A virus activity of the extract and fractions was assessed using Cytopathic Effect (CPE) reduction assay, Hemagglutinin Assay (HA), and 50% Tissue Culture Infectious Doses (TCID50) method in Madin-Darby Canine Kidney (MDCK) cells. Results: The crude Pomegranate peel extract and its n-butanol and ethyl acetate fractions had the highest inhibitory effect against influenza A virus with IC50 value of 6. 45, 6. 07 and 5. 6 μ g/ml in MDCK cells, respectively. Our results also showed that, the production of virus was significantly reduced upon treatment with crude extract, n-butanol and ethyl acetate fractions in a dose-dependent manner (p<0. 05). Conclusion: Based on our results, the ethyl alcohol extract and its polar fractions of Pomegranate peel can inhibit influenza A virus replication in vitro. Therefore, further characterization of its active ingredients and the mechanism of action should be carried out.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    Moradi, Mohammad Taghi, KARIMI, ALI, SHAHRANI, MEHRDAD, HASHEMI, LEILA, & Ghaffari Goosheh, Mohammad Saleh. (2019). Anti-Influenza Virus Activity and Phenolic Content of Pomegranate (Punica granatum L. ) Peel Extract and Fractions. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 11(4), 285-291. SID. https://sid.ir/paper/314047/en

    Vancouver: Copy

    Moradi Mohammad Taghi, KARIMI ALI, SHAHRANI MEHRDAD, HASHEMI LEILA, Ghaffari Goosheh Mohammad Saleh. Anti-Influenza Virus Activity and Phenolic Content of Pomegranate (Punica granatum L. ) Peel Extract and Fractions. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2019;11(4):285-291. Available from: https://sid.ir/paper/314047/en

    IEEE: Copy

    Mohammad Taghi Moradi, ALI KARIMI, MEHRDAD SHAHRANI, LEILA HASHEMI, and Mohammad Saleh Ghaffari Goosheh, “Anti-Influenza Virus Activity and Phenolic Content of Pomegranate (Punica granatum L. ) Peel Extract and Fractions,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 11, no. 4, pp. 285–291, 2019, [Online]. Available: https://sid.ir/paper/314047/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button