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Information Journal Paper

Title

Short Communication: Gene Expression and Levels of TGF-Β in PBMC Is Associated with Severity of Symptoms in Chronic Heart Failure

Pages

  132-134

Abstract

 Background: TGF-β 1 is known to promote cardiac remodeling and fibrosis during Congestive Heart Failure (CHF). In this study, an attempt was made to investigate expression of Transforming growth factor beta1 (TGF-β 1) and relative expansion or contraction of regulatory T-cell (Tregs) population in peripheral blood of patients with Chronic heart failure (CHF). Methods: Real-time PCR assay was used to investigate expression and post-stimulation levels of TGF-β 1 in cell culture supernatant of Peripheral Blood Mononuclear Cells (PBMC) of 42 patients with CHF and 42 controls. Flow cytometry was used to identify relative counts of CD4+CD25+FoxP3+ Tregs. Results: PBMCs in patients with CHF expressed higher levels of TGF-β 1 compared to controls. Post-stimulation levels of TGF-β 1 expression were significantly higher in New York Heart Association (NYHA) functional class IV patients compared to stage I patients. Tregs were significantly expanded in PBMC in CHF, while the CD4+ helper Tcells were unchanged. Treg expansion was more significant in NYHA functional class I patients compared to class IV patients. Conclusion: Expansion of Treg population in CHF provides an extrinsic source for TGF-β 1 production to induce reactive fibrosis and cardiac remodeling. Relative decrease in Treg population at advanced stages of CHF is indicative of a loss of regulatory characteristics in these cells and unopposed proinflammatory milieu.

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    Cite

    APA: Copy

    Saadati, Samaneh, Eskandari, Vajiheh, RAHMANI, FARZANEH, MAHMOUDI, MOHAMMAD JAFAR, Rahnemoon, Zahra, RAHMATI, ZAHRA, gorzin, fatemeh, HEDAYAT, MONA, AMIRZARGAR, ALI AKBAR, & REZAEI, NIMA. (2020). Short Communication: Gene Expression and Levels of TGF-Β in PBMC Is Associated with Severity of Symptoms in Chronic Heart Failure. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 12(2), 132-134. SID. https://sid.ir/paper/314074/en

    Vancouver: Copy

    Saadati Samaneh, Eskandari Vajiheh, RAHMANI FARZANEH, MAHMOUDI MOHAMMAD JAFAR, Rahnemoon Zahra, RAHMATI ZAHRA, gorzin fatemeh, HEDAYAT MONA, AMIRZARGAR ALI AKBAR, REZAEI NIMA. Short Communication: Gene Expression and Levels of TGF-Β in PBMC Is Associated with Severity of Symptoms in Chronic Heart Failure. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2020;12(2):132-134. Available from: https://sid.ir/paper/314074/en

    IEEE: Copy

    Samaneh Saadati, Vajiheh Eskandari, FARZANEH RAHMANI, MOHAMMAD JAFAR MAHMOUDI, Zahra Rahnemoon, ZAHRA RAHMATI, fatemeh gorzin, MONA HEDAYAT, ALI AKBAR AMIRZARGAR, and NIMA REZAEI, “Short Communication: Gene Expression and Levels of TGF-Β in PBMC Is Associated with Severity of Symptoms in Chronic Heart Failure,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 12, no. 2, pp. 132–134, 2020, [Online]. Available: https://sid.ir/paper/314074/en

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