DISRUPTION OF STROMAL-DERIVED FACTOR-1/CHEMOKINE RECEPTOR 4 BY SIMVASTATIN

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MASORI M.; JALILI A.; NAKAYA Y.

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Journal: INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL Year:2010 | Volume:4 | Issue:1 Page(s): 1-7

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Title

DISRUPTION OF STROMAL-DERIVED FACTOR-1/CHEMOKINE RECEPTOR 4 BY SIMVASTATIN

Author(s)

MASORI M. | JALILI A. | NAKAYA Y. | Issue Writer Certificate

Keywords

SDF-1

CXCR4

MONOCYTES

ATHEROSCLEROSIS

SIMVASTATIN

Abstract

Background: The alpha chemokine, stromal-derived factor (SDF)-1 is produced by bone marrow stromal cells and other cells, especially damaged tissues. SDF-1 receptor, a chemokine receptor 4 (CXCR4), is expressed on inflammatory cells and that SDF-1/CXCR4 axis plays a critical role in migration of inflammatory cells. In cardiovascular diseases, SDF-1 is produced by endothelial cells and plaques and that SDF-1 chemoattracts MONOCYTES to the endothelial cells resulting in a local inflammation. SIMVASTATIN, a cholesterol-lowering agent, is a general drug for treatment of cardiovascular diseases. However, its molecular mechanism has not yet been completely elucidated.Method: Herein, we investigated the role of SIMVASTATIN on the SDF- 1/CXCR4 axis by employing flow cytometry, RT-PCR, chemotaxis and adhesion assays. Results: SIMVASTATIN (i) downregulates CXCR4 expression on monocytic cell line (THP-1) and primary monocyte in a dose-dependent manner, (ii) inhibits adhesion of MONOCYTES to endothelial cells and (iii) decreases SDF-1 production by endothelial cells. Moreover, preincubation with SIMVASTATIN significantly decreased the migration of THP-1 towards the SDF-1 gradient.Conclusion: All together our data indicate that SIMVASTATIN inhibits the binding of MONOCYTES to endothelial cells through disrupting of the SDF-1/CXCR4 axis.

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APA: Copy

MASORI, M., JALILI, A., & NAKAYA, Y.. (2010). DISRUPTION OF STROMAL-DERIVED FACTOR-1/CHEMOKINE RECEPTOR 4 BY SIMVASTATIN. INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL, 4(1), 1-7. SID. https://sid.ir/paper/314081/en

Vancouver: Copy

MASORI M., JALILI A., NAKAYA Y.. DISRUPTION OF STROMAL-DERIVED FACTOR-1/CHEMOKINE RECEPTOR 4 BY SIMVASTATIN. INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL[Internet]. 2010;4(1):1-7. Available from: https://sid.ir/paper/314081/en

IEEE: Copy

M. MASORI, A. JALILI, and Y. NAKAYA, “DISRUPTION OF STROMAL-DERIVED FACTOR-1/CHEMOKINE RECEPTOR 4 BY SIMVASTATIN,” INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL, vol. 4, no. 1, pp. 1–7, 2010, [Online]. Available: https://sid.ir/paper/314081/en

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