A COMPARATIVE STUDY OF THE MANAGEMENT OF STAGE 2 HYPERTENSION BY COMBINED THERAPY WITH LOSARTAN, AMLODIPINE AND HYDROCHLOROTHIAZIDE

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JAFARZADEH ESFEHANI REZA; MAHMOODI GHARAI AZADEH; JAFARZADEH ESFEHANI ALI; REZAIE KALAT AFSANEH; ABBASI FAEZEH; JALAL YAZDI MAJID

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Journal: INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL Year:2012 | Volume:6 | Issue:3 (20) Page(s): 79-83

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Title

A COMPARATIVE STUDY OF THE MANAGEMENT OF STAGE 2 HYPERTENSION BY COMBINED THERAPY WITH LOSARTAN, AMLODIPINE AND HYDROCHLOROTHIAZIDE

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Keywords

ANGIOTENSIN RECEPTOR BLOCKER

CALCIUM CHANNEL BLOCKER

HYPERTENSION

Abstract

Background: The most effective and accurate treatment of hypertensive patients reduces cardiovascular events and improves the quality of life.Objective: This study compared the efficacy and safety of combined (combination therapy with an) angiotensin-receptor blocker (ARB) a calcium-channel blocker (CCB) (Losartan / Amloidipine 50/10mg) vs maximal combination doses of ARB with hydrochlorothiazide (Losartan /HCTZ 100/25 mg) and maximal combination doses of CCB with HCTZ (Amlodipine /HCTZ 10/25 mg) in the management of stage 2 HYPERTENSION.Methods: This randomized clinical trial (RTC) comprised 478 hypertensive patients with mean age 50.5±5.21 years, and took place between January 2010 and December 2011 in Vasei Hospital clinic in Sabzevar. Antihypertensive drugs were washed out after 5 days of discontinuation of drugs and the patients with mean blood pressure in sitting position ≥160 and <200 mmHg in systole and ≥100 and <110 mmHg in diastole were randomized into three groups: Losartan / Amilidipin 50/10 mg (n =164), Losartan / HCTZ 100/25 mg (n =155) and Amilidipin / HCTZ 10/25 mg (n =159). The end point was reaching the blood pressure below 140/90 within 56 days of treatment in each group.Results: There was a significant difference in systolic blood pressure reductions between treatment groups (P<0.001) and also there was a significant difference between groups in reducing diastolic blood pressure (P<0.01). The highest systolic and diastolic blood pressure reduction respectively was found in Amlodipine/losartane and losartane/HTCZ group. The ANCOVA analysis revealed that only treatment regimen had a significant effect (P=0.01) and other factor including Age, Gender, Diabetes Mellitus, Smoking and High serum cholesterol didn’t have significant effect on blood pressure reduction.Conclusion: ARB/CCB combination therapy reduced blood pressure more effectively than the maximal doses of ARB or CCB with HCTZ in stage 2 hypertensive patients within this period of study.

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APA: Copy

JAFARZADEH ESFEHANI, REZA, MAHMOODI GHARAI, AZADEH, JAFARZADEH ESFEHANI, ALI, REZAIE KALAT, AFSANEH, ABBASI, FAEZEH, & JALAL YAZDI, MAJID. (2012). A COMPARATIVE STUDY OF THE MANAGEMENT OF STAGE 2 HYPERTENSION BY COMBINED THERAPY WITH LOSARTAN, AMLODIPINE AND HYDROCHLOROTHIAZIDE. INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL, 6(3 (20)), 79-83. SID. https://sid.ir/paper/314190/en

Vancouver: Copy

JAFARZADEH ESFEHANI REZA, MAHMOODI GHARAI AZADEH, JAFARZADEH ESFEHANI ALI, REZAIE KALAT AFSANEH, ABBASI FAEZEH, JALAL YAZDI MAJID. A COMPARATIVE STUDY OF THE MANAGEMENT OF STAGE 2 HYPERTENSION BY COMBINED THERAPY WITH LOSARTAN, AMLODIPINE AND HYDROCHLOROTHIAZIDE. INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL[Internet]. 2012;6(3 (20)):79-83. Available from: https://sid.ir/paper/314190/en

IEEE: Copy

REZA JAFARZADEH ESFEHANI, AZADEH MAHMOODI GHARAI, ALI JAFARZADEH ESFEHANI, AFSANEH REZAIE KALAT, FAEZEH ABBASI, and MAJID JALAL YAZDI, “A COMPARATIVE STUDY OF THE MANAGEMENT OF STAGE 2 HYPERTENSION BY COMBINED THERAPY WITH LOSARTAN, AMLODIPINE AND HYDROCHLOROTHIAZIDE,” INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL, vol. 6, no. 3 (20), pp. 79–83, 2012, [Online]. Available: https://sid.ir/paper/314190/en

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