A STUDY ON THE RELATIONSHIP BETWEEN SERUM BETA 2-MICROGLOBULIN LEVELS, UNDERLYING CHRONIC KIDNEY DISEASE, AND PERIPHERAL ARTERIAL DISEASE IN HIGH-VASCULAR-RISK PATIENTS

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DE ASUA DIEGO REAL; PUCHADES RAMON; GARCLA POLO ILUMINADA; SUAREZ CARMEN

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Paper Information

Journal: INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL Year:2012 | Volume:6 | Issue:4 Page(s): 107-112

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Title

A STUDY ON THE RELATIONSHIP BETWEEN SERUM BETA 2-MICROGLOBULIN LEVELS, UNDERLYING CHRONIC KIDNEY DISEASE, AND PERIPHERAL ARTERIAL DISEASE IN HIGH-VASCULAR-RISK PATIENTS

Author(s)

DE ASUA DIEGO REAL | PUCHADES RAMON | GARCLA POLO ILUMINADA | SUAREZ CARMEN | Issue Writer Certificate

Keywords

ANKLE-BRACHIAL INDEX

BETA 2-MICROGLOBULIN

GLOMERULAR FILTRATION RATE

PERIPHERAL ARTERIAL DISEASE

RENAL INSUFFICIENCY

Abstract

Background: Serum BETA 2-MICROGLOBULIN (B2M) levels have been found to be increased in patients with PERIPHERAL ARTERIAL DISEASE (PAD), yet it is still unknown whether B2M correlates with PAD intensity.Objectives: We aim to evaluate the correlation between B2M and the ANKLE-BRACHIAL INDEX (ABI) values in high-vascular-risk patients.Methods: This is a cross-sectional study of 63 high-vascular-risk patients admitted to the Cardiology Department or evaluated as outpatients in the Internal Medicine Department of our institution. Patients were classified into two groups according to their ABI: patients without PAD (n=44, ABI values between 0.9 and 1.4) and patients with PAD (n=19, ABI values lower than 0.9 or higher than 1.4). We performed univariate and multivariate analysis based on a multiple linear regression model.Results: Serum B2M levels were higher in patients with pathological ABI values than in those without PAD (2.36±1.13 vs.1.80±0.65 mg/L; P<0.05). We found no correlation between B2M and ABI in our total population (r=-0.12) or in patients with PAD (r=-0.09; NS for both comparisons). Age, gender, arterial hypertension, estimated GLOMERULAR FILTRATION RATE (eGFR), uric acid, total cholesterol, and LDL-cholesterol correlated with B2M in the univariate analysis. In the final linear regression model, eGFR, uric acid and total cholesterol correlated independently with B2M (P<0.01).Conclusion: We found no correlation between B2M levels and ABI values in high-vascularrisk patients that could usefully help in the subsequent diagnosis of PAD. However, we observed a significant correlation between B2M and eGFR, even when renal function was only slightly impaired.

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APA: Copy

DE ASUA, DIEGO REAL, PUCHADES, RAMON, GARCLA POLO, ILUMINADA, & SUAREZ, CARMEN. (2012). A STUDY ON THE RELATIONSHIP BETWEEN SERUM BETA 2-MICROGLOBULIN LEVELS, UNDERLYING CHRONIC KIDNEY DISEASE, AND PERIPHERAL ARTERIAL DISEASE IN HIGH-VASCULAR-RISK PATIENTS. INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL, 6(4), 107-112. SID. https://sid.ir/paper/314204/en

Vancouver: Copy

DE ASUA DIEGO REAL, PUCHADES RAMON, GARCLA POLO ILUMINADA, SUAREZ CARMEN. A STUDY ON THE RELATIONSHIP BETWEEN SERUM BETA 2-MICROGLOBULIN LEVELS, UNDERLYING CHRONIC KIDNEY DISEASE, AND PERIPHERAL ARTERIAL DISEASE IN HIGH-VASCULAR-RISK PATIENTS. INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL[Internet]. 2012;6(4):107-112. Available from: https://sid.ir/paper/314204/en

IEEE: Copy

DIEGO REAL DE ASUA, RAMON PUCHADES, ILUMINADA GARCLA POLO, and CARMEN SUAREZ, “A STUDY ON THE RELATIONSHIP BETWEEN SERUM BETA 2-MICROGLOBULIN LEVELS, UNDERLYING CHRONIC KIDNEY DISEASE, AND PERIPHERAL ARTERIAL DISEASE IN HIGH-VASCULAR-RISK PATIENTS,” INTERNATIONAL CARDIOVASCULAR RESEARCH JOURNAL, vol. 6, no. 4, pp. 107–112, 2012, [Online]. Available: https://sid.ir/paper/314204/en

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