مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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1

Information Journal Paper

Title

THERAPEUTIC POTENTIAL OF UMBILICAL CORD BLOOD STEM CELLS ON BRAIN DAMAGE OF A MODEL OF STROKE

Pages

  121-126

Abstract

 Introduction: Human cord blood-derived STEM CELLs are a rich source of STEM CELLs as well as precursors. With regard to the researchers have focused on the therapeutic potential of STEM CELL in the neurological disease such as STROKE, the aim of this study was the investigation of the therapeutic effects of human cord blood-derived STEM CELLs in cerebral ischemia on rat.Methods: This study was carried out on young rats. Firstly, to create a laboratory model of ischemic STROKE, carotid artery of animals was occluded for 30 minutes. Then, UMBILICAL CORD BLOOD cells were isolated and labeled using bromodeoxyuridine and 2x105 cells were injected into the experimental group via the tail vein. Rats with hypoxic conditions were used as a sham group. A group of animals did not receive any injection or surgeries were used as a control.Results: Obtained results were evaluated based on behavior-al responses and immunohistochemistry, with emphasis on areas of putamen and caudate nucleus in the control, sham and experimental groups. Our results indicated that behavioral recovery was observed in the experimental group compared to the either the sham or the control group. However, histological studies demonstrated a low percent of tissue injury in the experimental group in comparison with the sham group.Conclusions: STEM CELL trans-plantation is beneficial for the brain tissue reparation after hypoxic ischemic cell death.

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    APA: Copy

    NIKRAVESH, MOHAMMAD REZA, JALALI, MEHDI, GHAFARIPOOR, HOSSEIN ALI, SANCHOOLI, JAVAD, HAMIDI, DARIOUSH, MOHAMMADI, SHABNAM, & SEGHATOLESLAM, MASOOMEH. (2011). THERAPEUTIC POTENTIAL OF UMBILICAL CORD BLOOD STEM CELLS ON BRAIN DAMAGE OF A MODEL OF STROKE. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, 3(4), 121-126. SID. https://sid.ir/paper/314867/en

    Vancouver: Copy

    NIKRAVESH MOHAMMAD REZA, JALALI MEHDI, GHAFARIPOOR HOSSEIN ALI, SANCHOOLI JAVAD, HAMIDI DARIOUSH, MOHAMMADI SHABNAM, SEGHATOLESLAM MASOOMEH. THERAPEUTIC POTENTIAL OF UMBILICAL CORD BLOOD STEM CELLS ON BRAIN DAMAGE OF A MODEL OF STROKE. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH[Internet]. 2011;3(4):121-126. Available from: https://sid.ir/paper/314867/en

    IEEE: Copy

    MOHAMMAD REZA NIKRAVESH, MEHDI JALALI, HOSSEIN ALI GHAFARIPOOR, JAVAD SANCHOOLI, DARIOUSH HAMIDI, SHABNAM MOHAMMADI, and MASOOMEH SEGHATOLESLAM, “THERAPEUTIC POTENTIAL OF UMBILICAL CORD BLOOD STEM CELLS ON BRAIN DAMAGE OF A MODEL OF STROKE,” JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, vol. 3, no. 4, pp. 121–126, 2011, [Online]. Available: https://sid.ir/paper/314867/en

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