مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

OXIDATIVE VERSUS THROMBOTIC STIMULATION OF PLATELETS DIFFERENTIALLY ACTIVATES SIGNALLING PATHWAYS

Pages

  61-65

Abstract

 Introduction: Atherosclerosis is one of the inflammatory underlying disease associated by oxidative stress and thrombotic agents. This study aimed to evaluate the potential role of cupper oxidized low-density lipoprotein (OxLDL) and thrombin for inducing mitogen activated protein kinases (MAPKs) in platelets.Methods: Phosphorylation of P38MAPK, Jun N-terminal Kinase (JNK), and Extracellular signal-regulated kinases (ERK1/2) and P-selectin expression were determined in lysates of washed human platelets pretreated with low doses of thrombin and cu2+-OxLDL By Enzyme-linked immunosorbent assay (ELISA). Pharmacological inhibition was performed by SB203580, PD980559 and SP6000125 for P38MAPK, ERK1/2 and JNK activity, respectively. The ratio of phosphorylated to total protein was used for normalizing the phospho proteins contents of cells.Results: OxLDL and thrombin significantly and differentially increased P-selectin expression (P<0.05), P38MAPK (P<0.05) and c-JNK (P<0.05) and ERK1/2 (P<0.05) phosphorylation in platelets. SB 203580 and SP6000125 significantly decreased P-selectin expression in both oxidative (P<0.05) and thrombotic (P<0.05) activated platelets.Conclusion: Our results indicated that MAPK inhibitors can reduce atherothrombotic events via alterations in P-selectin expression suggesting that these inhibitors may be useful in the inhibition of atheroma development.

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    APA: Copy

    KARIMI, POURAN, & RASHTCHIZADEH, NADEREH. (2013). OXIDATIVE VERSUS THROMBOTIC STIMULATION OF PLATELETS DIFFERENTIALLY ACTIVATES SIGNALLING PATHWAYS. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, 5(2), 61-65. SID. https://sid.ir/paper/314917/en

    Vancouver: Copy

    KARIMI POURAN, RASHTCHIZADEH NADEREH. OXIDATIVE VERSUS THROMBOTIC STIMULATION OF PLATELETS DIFFERENTIALLY ACTIVATES SIGNALLING PATHWAYS. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH[Internet]. 2013;5(2):61-65. Available from: https://sid.ir/paper/314917/en

    IEEE: Copy

    POURAN KARIMI, and NADEREH RASHTCHIZADEH, “OXIDATIVE VERSUS THROMBOTIC STIMULATION OF PLATELETS DIFFERENTIALLY ACTIVATES SIGNALLING PATHWAYS,” JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, vol. 5, no. 2, pp. 61–65, 2013, [Online]. Available: https://sid.ir/paper/314917/en

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