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Information Journal Paper

Title

ANALYSIS OF THE MUTATIONS IN EXON 10 OF MEFV GENE IN PATIENTS WITH PREMATURE CORONARY HEART DISEASE IN WEST AZERBAIJAN PROVINCE OF IRAN

Pages

  20-239

Keywords

Abstract

 Introduction: Premature coronary heart disease (PCHD) affects public health and leads to death. PCHD has several genetic and environmental risk factors. The aim of this study was to analysis of the MUTATIONS in exon 10 of MEFV gene in patients with PCHD in West Azerbaijan province of Iran.Methods: Totally 41 PCHD patients who were admitted to the cardiology unit of Sayedoshohada hospital (Urmia, Iran) enrolled in the study. Selection of the patients was done based on the strict criteria, that is, who had a minimum of one angiographically documented coronary artery with the stenosis of 50%. MUTATIONS in exon 10 of MEFV gene were found by direct sequencing.Results: V726A, M680I, K695R, and A744S MUTATIONS with 2.44%, 1.22%, 1.22%, and 1.22%, allelic frequency were found, respectively. Five patients (12.2%) with PCHD carried at least one mutated MEFV allele. Heterozygote V726A was the most frequent mutation among tested cases (4.88%), followed by heterozygote M680I, heterozygote K695R, and heterozygote A744S.Conclusion: The results of the present study imply that the frequency of the MEFV gene exon 10 is significantly high in PCHD patients. This is the first report in its own kind in clinically diagnosed PCHD patients of Iranian Azeri Turkish population.

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    APA: Copy

    BAGHERI, MORTEZA, KHADEM VATANI, KAMAL, SEYED MOHAMMAD ZAD, MIR HOSSEIN, ABDI RAD, ISA, RAHIMI, BEHZAD, Rostamzadeh, Alireza, GODARZI, MOJTABA, & ASHENA, SHABNAM. (2018). ANALYSIS OF THE MUTATIONS IN EXON 10 OF MEFV GENE IN PATIENTS WITH PREMATURE CORONARY HEART DISEASE IN WEST AZERBAIJAN PROVINCE OF IRAN. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, 10(1), 20-239. SID. https://sid.ir/paper/314930/en

    Vancouver: Copy

    BAGHERI MORTEZA, KHADEM VATANI KAMAL, SEYED MOHAMMAD ZAD MIR HOSSEIN, ABDI RAD ISA, RAHIMI BEHZAD, Rostamzadeh Alireza, GODARZI MOJTABA, ASHENA SHABNAM. ANALYSIS OF THE MUTATIONS IN EXON 10 OF MEFV GENE IN PATIENTS WITH PREMATURE CORONARY HEART DISEASE IN WEST AZERBAIJAN PROVINCE OF IRAN. JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH[Internet]. 2018;10(1):20-239. Available from: https://sid.ir/paper/314930/en

    IEEE: Copy

    MORTEZA BAGHERI, KAMAL KHADEM VATANI, MIR HOSSEIN SEYED MOHAMMAD ZAD, ISA ABDI RAD, BEHZAD RAHIMI, Alireza Rostamzadeh, MOJTABA GODARZI, and SHABNAM ASHENA, “ANALYSIS OF THE MUTATIONS IN EXON 10 OF MEFV GENE IN PATIENTS WITH PREMATURE CORONARY HEART DISEASE IN WEST AZERBAIJAN PROVINCE OF IRAN,” JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH, vol. 10, no. 1, pp. 20–239, 2018, [Online]. Available: https://sid.ir/paper/314930/en

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