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Title

FREQUENCY OF GENES ENCODING ERYTHROMYCIN RIBOSOMAL METHYLASES AMONG STAPHYLOCOCCUS AUREUS CLINICAL ISOLATES WITH DIFFERENT D-PHENOTYPES IN TEHRAN, IRAN

Pages

  161-167

Abstract

 Background and Objectives: Macrolide, lincosamide and streptogramin type B (MLSB) antibiotics are important in the treatment of STAPHYLOCOCCUS AUREUS infections and existence of isolates with ability to resist against MLSB antibiotics is worrisome.Materials and Methods: In this cross sectional study, 101 S. aureus isolates were collected from patients of five selected hospitals in Tehran over a period of five months. Disk diffusion tests and differentiation between constitutive and inducible resistances were carried out by D-TEST. The presence of mecA, MSRA, ermA and ERMC genes were detected using PCR or multiplex PCR.Results: Out of 101 S. aureus isolates, 58 (57.4%) were methicillin resistant and 57 (56.4%) expressed resistance to erythromycin. The prevalence of constitutive MLSB (cMLSB), inducible MLSB (iMLSB) and MS (Negative) phenotype in all erythromycin resistant isolates were 71.9, 26.3 and 1.7%, respectively. Out of all the erythromycin resistant isolates, 57.8% harbored both ermA and ERMC genes which possessed constitutive resistance. 8.7% of the isolates contained ermA gene alone which possessed inducible resistance with D phenotype and 5.2% of isolates just contained ERMC gene which had inducible resistance with D+ phenotype. MSRA gene was detected in 3.5% of the erythromycin resistant S. aureus isolates with constitutive resistance. None of the genes were detected among MS phenotypes.Conclusion: In this study, most of S. aureus isolates carried both ermA and ERMC genes and there was a significant relationship (P value ≤0.05) between different resistance phenotypes and erm genes.

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    APA: Copy

    HOSSEINI, SAREH SADAT, NIAKAN, MOHAMMAD, SADERI, HORIEH, MOTALLEBI, MITRA, TAHERIKALANI, MOROVAT, ASADOLLAHI, KHAIROLLAH, & EMANEINI, MOHAMMAD. (2016). FREQUENCY OF GENES ENCODING ERYTHROMYCIN RIBOSOMAL METHYLASES AMONG STAPHYLOCOCCUS AUREUS CLINICAL ISOLATES WITH DIFFERENT D-PHENOTYPES IN TEHRAN, IRAN. IRANIAN JOURNAL OF MICROBIOLOGY, 8(3), 161-167. SID. https://sid.ir/paper/315377/en

    Vancouver: Copy

    HOSSEINI SAREH SADAT, NIAKAN MOHAMMAD, SADERI HORIEH, MOTALLEBI MITRA, TAHERIKALANI MOROVAT, ASADOLLAHI KHAIROLLAH, EMANEINI MOHAMMAD. FREQUENCY OF GENES ENCODING ERYTHROMYCIN RIBOSOMAL METHYLASES AMONG STAPHYLOCOCCUS AUREUS CLINICAL ISOLATES WITH DIFFERENT D-PHENOTYPES IN TEHRAN, IRAN. IRANIAN JOURNAL OF MICROBIOLOGY[Internet]. 2016;8(3):161-167. Available from: https://sid.ir/paper/315377/en

    IEEE: Copy

    SAREH SADAT HOSSEINI, MOHAMMAD NIAKAN, HORIEH SADERI, MITRA MOTALLEBI, MOROVAT TAHERIKALANI, KHAIROLLAH ASADOLLAHI, and MOHAMMAD EMANEINI, “FREQUENCY OF GENES ENCODING ERYTHROMYCIN RIBOSOMAL METHYLASES AMONG STAPHYLOCOCCUS AUREUS CLINICAL ISOLATES WITH DIFFERENT D-PHENOTYPES IN TEHRAN, IRAN,” IRANIAN JOURNAL OF MICROBIOLOGY, vol. 8, no. 3, pp. 161–167, 2016, [Online]. Available: https://sid.ir/paper/315377/en

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