ANTIMICROBIAL EFFECTS OF FERULA GUMMOSA BOISS GUM AGAINST EXTENDED-SPECTRUM $#946;-LACTAMASE PRODUCING ACINETOBACTER CLINICAL ISOLATES

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FARID AFSHAR FATEMEH; SAFFARIAN PARVANEH; MAHMOODZADEH HOSSEINI HAMIDEH; SATTARIAN FERESHTEH; AMIN MOHSEN; IMANI FOOLADI ABBAS ALI

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Journal: Iranian Journal of Microbiology Year:2016 | Volume:8 | Issue:4 Page(s): 0-0

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Title

ANTIMICROBIAL EFFECTS OF FERULA GUMMOSA BOISS GUM AGAINST EXTENDED-SPECTRUM $#946;-LACTAMASE PRODUCING ACINETOBACTER CLINICAL ISOLATES

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Keywords

ACINETOBACTER SPP.

ANTIBIOTIC RESISTANCE

ANTIMICROBIAL ACTIVITY

ESBLS

FERULA GUMMOSA BOISS

Abstract

Background and Objectives: ACINETOBACTER SPP. are important causes of nosocomial infections. They possess various antibioticresistance mechanisms including extended spectrum beta lactamases (ESBLs). The aim of this study was to determineantibiotic resistance profile of Acinetobacter clinical isolates especially among ESBL-producing strains and to investigatethe antimicrobial effects of oleo-gum-resin extract and essential oil of FERULA GUMMOSA BOISS.Materials and Methods: 120 Acinetobacter strains were isolated from various clinical samples of hospitalized patients inBaqiyatallah hospital, Tehran during 2011-2012. Antibiotic susceptibility test was performed on the isolates using disk diffusionmethod. To detect and confirm the ESBL-positive isolates, phenotypic and genotypic tests were performed. Three typesof F. gummosa oleo-gum-resin extracts and essential oils were prepared and the bioactive components of F. gummosa Boissextracts were determined by GC-Mass chromatography. F. gummosa ANTIMICROBIAL ACTIVITY was evaluated against standardstrain of Acinetobacter baumannii (ATCC19606) as well as Acinetobacter clinical isolates using well and disk diffusionmethods. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined bybroth microdilution method.Results: 46 isolates were resistant to all tested antibiotics. All clinical isolates were resistant to cefotaxime.12.94% of theisolates were phenotypically ESBL-producing among which 94.2% carried ESBL genes (blaPER-1, blaOXA-4 and blaCTX-M)detected by PCR. Oleo-gum-resin of F. gummosa had significant antibacterial activity and alcoholic essential oil had higherinhibitory effect on Acinetobacter strains (MIC of 18.75 mg/ml).Conclusion: Ferula gummosa extract contained components with well-known antimicrobial effects.

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APA: Copy

FARID AFSHAR, FATEMEH, SAFFARIAN, PARVANEH, MAHMOODZADEH HOSSEINI, HAMIDEH, SATTARIAN, FERESHTEH, AMIN, MOHSEN, & IMANI FOOLADI, ABBAS ALI. (2016). ANTIMICROBIAL EFFECTS OF FERULA GUMMOSA BOISS GUM AGAINST EXTENDED-SPECTRUM $#946;-LACTAMASE PRODUCING ACINETOBACTER CLINICAL ISOLATES. IRANIAN JOURNAL OF MICROBIOLOGY, 8(4), 0-0. SID. https://sid.ir/paper/315400/en

Vancouver: Copy

FARID AFSHAR FATEMEH, SAFFARIAN PARVANEH, MAHMOODZADEH HOSSEINI HAMIDEH, SATTARIAN FERESHTEH, AMIN MOHSEN, IMANI FOOLADI ABBAS ALI. ANTIMICROBIAL EFFECTS OF FERULA GUMMOSA BOISS GUM AGAINST EXTENDED-SPECTRUM $#946;-LACTAMASE PRODUCING ACINETOBACTER CLINICAL ISOLATES. IRANIAN JOURNAL OF MICROBIOLOGY[Internet]. 2016;8(4):0-0. Available from: https://sid.ir/paper/315400/en

IEEE: Copy

FATEMEH FARID AFSHAR, PARVANEH SAFFARIAN, HAMIDEH MAHMOODZADEH HOSSEINI, FERESHTEH SATTARIAN, MOHSEN AMIN, and ABBAS ALI IMANI FOOLADI, “ANTIMICROBIAL EFFECTS OF FERULA GUMMOSA BOISS GUM AGAINST EXTENDED-SPECTRUM $#946;-LACTAMASE PRODUCING ACINETOBACTER CLINICAL ISOLATES,” IRANIAN JOURNAL OF MICROBIOLOGY, vol. 8, no. 4, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/315400/en

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