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Information Journal Paper

Title

Sensitivity of levofloxacin in combination with ampicillin-sulbactam and tigecycline against multidrug-resistant Acinetobacter baumannii

Pages

  19-25

Abstract

 Background and Objectives: The selection of alternative treatment options with antibiotic combinations may be used for successful managing of multidrug-resistant Acinetobacter baumannii. The aim of this study was to determine the Synergistic effects of ampicillin-sulbactam combined with either levofloxacin or tigecycline against MDR A. baumannii. Materials and Methods: A total 124 of A. baumannii isolates collected from clinical samples of hospitalized patients which assessed for antibiotic susceptibility using disk diffusion method. E-test was used on 10 MDR A. baumannii isolates to determine the minimum inhibitory concentration (MIC) of ampicillin-sulbactam, levofloxacin and tigecycline. Any Synergistic effects were evaluated at their own MIC using E-test assay at 37° C for 24 hours. Synergy was defined as a fractional inhibitory concentration index (FICI) of ≤ 0. 5. Results: Levofloxacin plus ampicillin-sulbactam combination was found to have Synergistic effects (FIC index: ≤ 0. 5) in 90% of the isolates, but there was no Synergistic effect for ampicillin-sulbactam/tigecycline and tigecycline/ levofloxacin combination. The antagonist effect in 50% of isolates (FIC index: >2) showed in combination of levofloxacin/tigecycline. Conclusion: The emergence of multidrug A. baumannii isolates requires evaluating by combination therapy. The combination of levofloxacin plus a bactericidal antibiotic such as ampicillin-sulbactam is recommended. Results should be confirmed by clinical studies.

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    APA: Copy

    Madadi Goli, Nahid, MONIRI, REZVAN, BAGHERI JOSHEGHANI, SAREH, & Dasteh Goli, Nilufar. (2017). Sensitivity of levofloxacin in combination with ampicillin-sulbactam and tigecycline against multidrug-resistant Acinetobacter baumannii. IRANIAN JOURNAL OF MICROBIOLOGY, 9(1), 19-25. SID. https://sid.ir/paper/315489/en

    Vancouver: Copy

    Madadi Goli Nahid, MONIRI REZVAN, BAGHERI JOSHEGHANI SAREH, Dasteh Goli Nilufar. Sensitivity of levofloxacin in combination with ampicillin-sulbactam and tigecycline against multidrug-resistant Acinetobacter baumannii. IRANIAN JOURNAL OF MICROBIOLOGY[Internet]. 2017;9(1):19-25. Available from: https://sid.ir/paper/315489/en

    IEEE: Copy

    Nahid Madadi Goli, REZVAN MONIRI, SAREH BAGHERI JOSHEGHANI, and Nilufar Dasteh Goli, “Sensitivity of levofloxacin in combination with ampicillin-sulbactam and tigecycline against multidrug-resistant Acinetobacter baumannii,” IRANIAN JOURNAL OF MICROBIOLOGY, vol. 9, no. 1, pp. 19–25, 2017, [Online]. Available: https://sid.ir/paper/315489/en

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